{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:01:49Z","timestamp":1772812909525,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T00:00:00Z","timestamp":1101686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p> <jats:italic>Introduction:<\/jats:italic> We previously reported that a normal ventricle can demonstrate two types of ventricular fibrillation (VF), depending on the underlying electrophysiologic characteristics at the time of VF induction. We hypothesize that the two types of VF can coexist in acutely ischemic ventricles.<\/jats:p><jats:p> <jats:italic>Methods and Results:<\/jats:italic> Optical mapping studies were performed with di\u20104ANEPPS in 15 Langendorff\u2010perfused rabbit hearts. Coronary artery branches were ligated to create regional ischemia in 10 hearts. Action potential duration measured to 50% repolarization (APD<jats:sub><jats:bold>50<\/jats:bold><\/jats:sub>) during ischemia showed an area with uniformly shortened APD<jats:bold><jats:sub>50<\/jats:sub><\/jats:bold> (zone 1), an area with normal or lengthened APD<jats:bold><jats:sub>50<\/jats:sub><\/jats:bold> (zone 3), and an area in between with an APD<jats:sub><jats:bold>50<\/jats:bold><\/jats:sub> gradient (zone 2). Ischemia flattened APD restitution (APDR) slope and reduced conduction velocity in zone 1, creating a condition for type II VF. APDR steepened and the conduction velocity changed little in the nonischemic zone (zone 3), creating a condition for type I VF. During induced VF, the dominant frequency in zones 2 and 3 progressively increased after ischemia onset. The dominant frequency in zone 1 (ischemic zone) first decreased and then slightly increased but typically remained less than the dominant frequency in zone 3. The number of wavebreaks increased with time in all three zones (baseline: 4.3 \u00b1 1.5; 30 min: 11.7 \u00b1 5.6; 60 min: 15.6 \u00b1 11 per frame; P &lt; 0.01).<\/jats:p><jats:p> <jats:italic>Conclusion:<\/jats:italic> Two types of VF can coexist during acute regional ischemia. Both ischemic and nonischemic regions develop proarrhythmic changes during regional ischemia, thus contributing to increased ventricular vulnerability to VF and sudden death during acute coronary occlusion.<\/jats:p>","DOI":"10.1046\/j.1540-8167.2004.04337.x","type":"journal-article","created":{"date-parts":[[2004,12,13]],"date-time":"2004-12-13T22:54:30Z","timestamp":1102978470000},"page":"1433-1440","source":"Crossref","is-referenced-by-count":31,"title":["Coexistence of Two Types of Ventricular Fibrillation During Acute Regional Ischemia in Rabbit Ventricle"],"prefix":"10.1111","volume":"15","author":[{"given":"YEN\u2010BIN","family":"LIU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HUI\u2010NAM","family":"PAK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SCOTT T.","family":"LAMP","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUJI","family":"OKUYAMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIDEKI","family":"HAYASHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TSU\u2010JUEY","family":"WU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAMES N.","family":"WEISS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PENG\u2010SHENG","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHIEN\u2010FONG","family":"LIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,12,13]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra000650"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8627(05)70196-6"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.10.2526"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00093-X"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90493-4"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.12.1103"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.14.1664"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.090492697"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.8.955"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.6.H2689"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.16.1688"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000031334.49170.FB"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2002.01173.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2002.01141.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01723-5"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.5.H1635"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.1.H253"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.00716.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.4.H1667"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.11.1318"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.69.4.965"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00013-9"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.5.1131"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1999.tb00282.x"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000061917.23107.F7"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000094404.26004.07"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.3035"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000016702.86180.F6"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2003.03234.x"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1540-8167.2004.04337.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1540-8167.2004.04337.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1046\/j.1540-8167.2004.04337.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1540-8167.2004.04337.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T03:58:57Z","timestamp":1694404737000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1540-8167.2004.04337.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1046\/j.1540-8167.2004.04337.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1540-8167.2004.04337.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}