{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:11:32Z","timestamp":1784326292069,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T00:00:00Z","timestamp":1101686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p><jats:italic>Introduction:<\/jats:italic>We tested the hypothesis that AZD7009 terminates induced atrial fibrillation (AF) and flutter (AFL) and prevents their reinduction, and that effects on refractoriness, conduction, and excitability are predominantly on the atria.<\/jats:p><jats:p><jats:italic>Methods and Results:<\/jats:italic>Thirty\u2010eight electrophysiologic studies were performed during AZD7009 infusion in 11 dogs with sterile pericarditis. The effects of AZD7009 on refractoriness, conduction, and capture threshold were studied and its antiarrhythmic efficacy tested. Simultaneous multisite biatrial mapping was performed in 7 dogs to assess arrhythmia termination. AZD7009 prolonged arrhythmia cycle length (CL) from 121 \u00b1 7.8 to 157 \u00b1 9.7 msec (P &lt; 0.001) before terminating 23 of 23 AF\/AFL episodes. Mapping demonstrated that AF\/AFL CL prolonged and then terminated in area(s) of slow conduction in a reentrant circuit. Arrhythmia reinduction failed in 19 of 20 attempts. At 400\u2010msec CL, atrial and ventricular refractoriness and QT interval increased 33%, 17% (P &lt; 0.001 vs atrial refractoriness), and 9%, respectively. Atrial capture threshold increased in a CL\u2010dependent manner: 1.8 \u00b1 0.3 to 2.2 \u00b1 0.3 mA (CL 400 msec); 2.1 \u00b1 0.3 to 2.8 \u00b1 0.5 mA (CL 300 msec), and 2.2 \u00b1 0.3 to 5.3 \u00b1 0.8 mA (CL 200 msec). Only minor nonsignificant changes occurred in the ventricles: 0.95 \u00b1 0.05 to 0.98 \u00b1 0.06 mA (CL 400 msec), and 1.14 \u00b1 0.12 to 1.16 \u00b1 0.13 mA (CL 333 msec). Atrial conduction time increased 8 \u00b1 1.4 msec (CL 400 msec), 8.3 \u00b1 1.5 msec (CL 300 msec), and 13.2 \u00b1 1.6 msec (CL 200 msec, all P &lt; 0.001), but ventricular conduction time was unchanged.<\/jats:p><jats:p><jats:italic>Conclusion:<\/jats:italic>AZD7009 is highly efficacious in terminating AF\/AFL and preventing reinduction in this model. It exhibits marked effects on atrial electrophysiology but has only modest effects on the ventricle.<\/jats:p>","DOI":"10.1046\/j.1540-8167.2004.04354.x","type":"journal-article","created":{"date-parts":[[2004,12,13]],"date-time":"2004-12-13T22:54:30Z","timestamp":1102978470000},"page":"1444-1450","source":"Crossref","is-referenced-by-count":90,"title":["AZD7009:"],"prefix":"10.1111","volume":"15","author":[{"given":"ROBERT N.","family":"GOLDSTEIN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CELEEN","family":"KHRESTIAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LEIF","family":"CARLSSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALBERT L.","family":"WALDO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,12,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(86)80429-6"},{"key":"e_1_2_6_3_2","article-title":"AZD7009: A new atrial antifibrillatory compound that blocks recombinant hNav1.5 and potassium channels","author":"Persson F","year":"2005","journal-title":"J Cardiovasc Electrophysiol"},{"key":"e_1_2_6_4_2","first-page":"S159","article-title":"AZD7009: A new antifibrillatory compound that markedly delays atrial refractoriness in the anesthetised dog","volume":"1","author":"Duker G","year":"2004","journal-title":"Heart Rhythm"},{"key":"e_1_2_6_5_2","first-page":"2939","article-title":"AZD7009: A new atrial antifibrillatory compound that markedly delays atrial refractoriness and possesses low proarrhythmic activity in the anaesthetized rabbit","volume":"6","author":"Linhardt G","year":"2004","journal-title":"Eur Heart J"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(81)90393-3"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.2.511"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.6.2860"},{"key":"e_1_2_6_9_2","first-page":"IV","article-title":"Reliable pace termination of atrial fibrillation is possible","volume":"108","author":"Goldstein RN KC","year":"2003","journal-title":"Circulation"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","unstructured":"LauritaK SGTC KavuruM VessellH LiebmanJ WaldoAL:Interactive cardiac mapping I: Data aquisition. Proceedings of the IEEE Engineering in Medicine and Biology Society11th Annual International Conference 1989:204\u2010205.","DOI":"10.1109\/IEMBS.1989.95682"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","unstructured":"LauritaK TC KavuruM VessellH LiebmanJ.Data Acquisition system for cardiac mapping.Proceedings of the 10th Annual International Conference of the IEEE EMBS. November 4\u20107 1988:104\u2010105.","DOI":"10.1109\/IEMBS.1988.94427"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","unstructured":"SunG LK ThomasCW LiebmanJ WangJ WaldoAL:Interactive cardiac mapping II: Data analysis.Proceedings of the IEEE Engineering in Medicine and Biology Society 11th Annual International Conference 1989:206\u2010207.","DOI":"10.1109\/IEMBS.1989.95683"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.12.1354"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.50.2.175"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1540-8167.2004.04354.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1540-8167.2004.04354.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1046\/j.1540-8167.2004.04354.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1540-8167.2004.04354.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T08:58:20Z","timestamp":1734771500000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1540-8167.2004.04354.x"}},"subtitle":["A New Antiarrhythmic Drug with Predominant Effects on the Atria Effectively Terminates and Prevents Reinduction of Atrial Fibrillation and Flutter in the Sterile Pericarditis Model"],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1046\/j.1540-8167.2004.04354.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1540-8167.2004.04354.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}