{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:53:19Z","timestamp":1787669599435,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,3,11]],"date-time":"2005-03-11T00:00:00Z","timestamp":1110499200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p>This is the first report of Brugada syndrome revealed by beta\u2010blocker intoxication. A 24\u2010year\u2010old healthy man ingested propranolol (2.28 g) to commit suicide. After early gastric lavage, electrolytes, cardiac enzymes, chest X\u2010ray, and echocardiography were normal. Dosages of psychotropic drugs were negative. ECG showed a typical coved\u2010type pattern of Brugada syndrome. Follow\u2010up showed partial ECG normalization of the discrete saddleback\u2010type pattern. The ajmaline\u2010 test confirmed Brugada syndrome. These ECG modifications may be explained by the stabilizing membrane effect of high concentration of propranolol and\/or inhibition of I<jats:bold><jats:sub>CaL<\/jats:sub><\/jats:bold>. This case illustrates the possible deleterious effects of beta\u2010blockers in patients with Brugada syndrome.<\/jats:p>","DOI":"10.1046\/j.1540-8167.2005.40564.x","type":"journal-article","created":{"date-parts":[[2005,3,11]],"date-time":"2005-03-11T09:27:03Z","timestamp":1110533223000},"page":"348-351","source":"Crossref","is-referenced-by-count":30,"title":["Propranolol Intoxication Revealing a Brugada Syndrome"],"prefix":"10.1111","volume":"16","author":[{"given":"PHILIP","family":"AOUATE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JEROME","family":"CLERC","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PHILIPPE","family":"VIARD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAMAL","family":"SEOUD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,3,11]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0102.101354"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.00061.x"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1054\/jelc.2001.26318"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03601.x"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00613-3"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2003.00044.x"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2002.t01-1-00856.x"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2004.00579.x"},{"key":"e_1_2_4_10_2","article-title":"Brugada syndrome","author":"Francis J","year":"2004","journal-title":"Int J Cardiol"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eupc.2003.11.009"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.9.2277"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000066319.56234.C8"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2002.129829"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(97)00106-X"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.00108.x"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000034169.45752.4A"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.15.1660"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/096032718300200307"},{"key":"e_1_2_4_20_2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.5694\/j.1326-5377.1991.tb142238.x","article-title":"Propranolol overdose\u2014A dramatic response to calcium chloride","volume":"19","author":"Brimacombe JR","year":"1991","journal-title":"Med J Aust"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/emj.20.4.393"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1540-8167.2005.40564.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1540-8167.2005.40564.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T23:49:43Z","timestamp":1696981783000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1540-8167.2005.40564.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["10.1046\/j.1540-8167.2005.40564.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1540-8167.2005.40564.x","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}