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Zahlreiche epidemiologische, pathophysiologische und klinische Studien zeigen diesen protektiven Effekt, der vom Ausma\u00df der infekti\u00f6sen Korpusgastritis und der dadurch verminderten S\u00e4uresekretion abh\u00e4ngt. \u2028Bei der Behandlungsstrategie der Reflux\u00f6sophagitis mit PPI (Protonenpumpen\u2010Inhibitoren) n\u00fctzt dieser biologische antisekretorische Effekt von H.\u2003p. jedoch, sowohl bei Akut\u2010 als auch bei Langzeittherapie, nur einer Minorit\u00e4t der Patienten. Nach wie vor umstritten ist die Entstehung einer atrophischen Gastritis bei Refluxpatienten unter PPI\u2010Langzeittherapie. \u2028Nach dem derzeitigen Stand des Wissens ist es anzuraten, die H.\u2003p.\u2010Eradikation auf die gut etablierten Indikationen zu beschr\u00e4nken.<\/jats:p>","DOI":"10.1046\/j.1563-2571.2000.00029.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:52:02Z","timestamp":1047347522000},"page":"122-125","source":"Crossref","is-referenced-by-count":3,"title":["Helicobacter pylori und gastro\u00f6sophageale Refluxkrankheit"],"prefix":"10.1111","volume":"27","author":[{"given":"K.","family":"Sch\u00fctze","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,24]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"A117","article-title":"Does eradication of Helicobacter pylori influence the recurrence of symptoms in patients with sympomatic gastroesophageal reflux disease? 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