{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:08:03Z","timestamp":1760188083817},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,6,11]],"date-time":"2002-06-11T00:00:00Z","timestamp":1023753600000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Austriaca"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p><jats:bold>Summary:<\/jats:bold> We examined retrospectively in a long\u2010term observation study the outcome of patients with RA in Austria. Eighty\u2010one inpatients with definite rheumatoid arthritis (RA) completed a standardized clinical and laboratory examination 3\u200a\u2013\u200a8 times between 1978 and 1999. The course of the disease was assessed by determining the disease activity score (DAS), 28\u2010joint count (28 JC), 30 swollen joint count (30 SJC), proximal interphalangeal joint score (PIP), Ritchie index, Stoke index, Steinbrocker stage, and Larsen score. In a mean duration of follow\u2010up of 10 years, we observed a statistically significant improvement in PIP, Ritchie index, Stoke index, and DAS. Steinbrocker stage and Larsen score increased significantly. A high percentage of the patients did not receive any disease\u2010modifying antirheumatic drug (DMARD) within the first 2 years of disease. Of all drugs used, methotrexate (MTX) was continued longer than other DMARDs. The most frequent extra\u2010articular manifestation was sicca syndrome. In our long\u2010term follow\u2010up, a change in treatment from the onset of the disease in the 1980s to a more aggressive treatment within the last decade could be observed. However, with respect to the significant increase in Steinbrocker stage and Larsen score as well, an early aggressive therapy is required. With respect to the association of ANA and extra\u2010articular manifestations, elevated ANA should give rise to an exact organ screening. For the development of predictive factors for the outcome in patients with RA, it would be helpful to refer patients at risk to specialist care as soon as possible.<\/jats:p>","DOI":"10.1046\/j.1563-2571.2002.01043.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:52:37Z","timestamp":1047347557000},"page":"52-56","source":"Crossref","is-referenced-by-count":12,"title":["Long\u2010term Observation Study of Austrian Patients with Rheumatoid Arthritis"],"prefix":"10.1111","volume":"29","author":[{"given":"M.","family":"Skoumal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wottawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,6,11]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/29.2.120"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/XXVII.suppl_2.171"},{"key":"e_1_2_5_5_2","first-page":"2213","article-title":"Patients with rheumatoid arthritis benefit from early 2nd line therapy: 5 year follow up of a prospective double blind placebo controlled study","volume":"22","author":"Egsmose C","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.6.655"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.12.944"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/XXXIV.suppl_4.87"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.11.1106"},{"key":"e_1_2_5_10_2","first-page":"585","article-title":"Evidence of significant radiographic damage within the first 2 years of disease","volume":"16","author":"Fuchs HA","year":"1989","journal-title":"J Rheumatology"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.9.939"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009749409102128"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90477-1"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009748509104317"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507203330302"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/028418517701800415"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.12.1263"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.57.2.88"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270805"},{"key":"e_1_2_5_20_2","first-page":"841","article-title":"Taking mortality in rheumatoid arthritis seriously \u2013 predictive markers, socioeconomic status and comorbidity","volume":"13","author":"Pincus T","year":"1986","journal-title":"J Rheumatol"},{"key":"e_1_2_5_21_2","first-page":"1885","article-title":"Longterm drug therapy for rheumatoid arthritis in seven rheumatology private practices: II. 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