{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:48:10Z","timestamp":1774126090860,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,25]],"date-time":"2001-12-25T00:00:00Z","timestamp":1009238400000},"content-version":"vor","delay-in-days":1423,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[1998,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Modulation of cytokine secretion may be of interest in the treatment of Crohn's disease or ulcerative colitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The effect of three antioxidants \u2014 butylated hydroxyanisol, tetrahydropapaveroline and nordihydroguaiaretic acid \u2014 on the production of tumour necrosis factor (TNF), interleukin (IL) 1, IL\u20106 and IL\u20108 (measured by enzyme\u2010linked immunosorbent assay) by peripheral mononuclear cells and biopsies of inflamed colonic mucosa from inflammatory bowel disease patients were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed a decrease in IL\u20101 and IL\u20106 production by peripheral mononuclear cells from inflammatory bowel disease patients (approximately 50% of control). The three drugs did not decrease IL\u20106 and IL\u20108 secretion by colonic biopsies, whereas they did inhibit IL\u20101 and, to some degree, TNF production. The cytokine\u2010inhibitory effect of antioxidants seems to be more pronounced in ulcerative colitis than in Crohn's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that the studied antioxidants, or related compounds, may be of interest in inflammatory bowel disease treatment.<\/jats:p><\/jats:sec>","DOI":"10.1046\/j.1365-2362.1998.00257.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T15:41:39Z","timestamp":1047397299000},"page":"145-150","source":"Crossref","is-referenced-by-count":36,"title":["Antioxidants inhibit the <i>in vitro<\/i> production of inflammatory cytokines in Crohn's disease and ulcerative colitis"],"prefix":"10.1111","volume":"28","author":[{"family":"Reimund","sequence":"first","affiliation":[]},{"family":"Allison","sequence":"additional","affiliation":[]},{"family":"Muller","sequence":"additional","affiliation":[]},{"family":"Dumont","sequence":"additional","affiliation":[]},{"family":"Kenney","sequence":"additional","affiliation":[]},{"family":"Baumann","sequence":"additional","affiliation":[]},{"family":"Duclos","sequence":"additional","affiliation":[]},{"family":"Poindron","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,12,25]]},"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2362.1998.00257.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2362.1998.00257.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2362.1998.00257.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T07:46:37Z","timestamp":1694418397000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2362.1998.00257.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,2]]}},"alternative-id":["10.1046\/j.1365-2362.1998.00257.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2362.1998.00257.x","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,2]]}}}