{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:56:24Z","timestamp":1770699384256,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,10,30]],"date-time":"2003-10-30T00:00:00Z","timestamp":1067472000000},"content-version":"vor","delay-in-days":2189,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:p>Intranasal administration of protein antigen is an efficient way to induce mucosal tolerance. Suppressive mechanisms that might be involved in this phenomenon include down\u2010regulation of T\u2010helper type\u20101 (Th1)\u2010mediated processes by Th2 cells. However, since Th2 responses can also be subjected to mucosal tolerance, we wanted to investigate whether suppression of a typical Th1 response, such as a delayed\u2010type hypersensitivity (DTH) reaction by intranasal tolerance induction, was causally related to up\u2010regulation of Th2 responses. We therefore treated mice either systemically or locally with anti\u2010interleukin\u20104 (IL\u20104) or anti\u2010IL\u201010 antibodies before intranasal tolerance induction or before sensitization for DTH to see whether we could prevent or abrogate tolerance. Although the up\u2010regulation of antigen\u2010specific IgE levels in tolerant mice could be prevented by anti\u2010IL\u20104 treatment, the extent of tolerance as measured by suppression of DTH was not affected. We therefore conclude that up\u2010regulation of Th2 responses observed after intranasal tolerance induction is an additional or consequential rather than a necessary reaction.<\/jats:p>","DOI":"10.1046\/j.1365-2567.1997.00356.x","type":"journal-article","created":{"date-parts":[[2003,11,2]],"date-time":"2003-11-02T15:47:45Z","timestamp":1067788065000},"page":"328-333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Mucosal tolerance is associated with, but independent of, up\u2010regulation Th2 responses"],"prefix":"10.1111","volume":"92","author":[{"given":"D. A. W.","family":"WOLVERS","sequence":"first","affiliation":[]},{"given":"M. J. F.","family":"VAN DER CAMMEN","sequence":"additional","affiliation":[]},{"given":"G.","family":"KRAAL","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2003,10,30]]},"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2567.1997.00356.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2567.1997.00356.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2567.1997.00356.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T08:08:22Z","timestamp":1694419702000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2567.1997.00356.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,11]]}},"alternative-id":["10.1046\/j.1365-2567.1997.00356.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2567.1997.00356.x","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11]]},"assertion":[{"value":"2003-10-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}