{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:28:19Z","timestamp":1775060899245,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,10,30]],"date-time":"2003-10-30T00:00:00Z","timestamp":1067472000000},"content-version":"vor","delay-in-days":2159,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[1997,12]]},"abstract":"<jats:p>Depletion of both natural killer 1.1<jats:sup>+<\/jats:sup> (NK1<jats:sup>+<\/jats:sup>) intermediate \u03b1\u03b2 T\u2010cell receptor (int T) cells and NK cells by <jats:italic>in vivo<\/jats:italic> treatment with anti\u2010NK1 antibody greatly increased hepatic metastases of intravenously injected EL4 cells as well as pulmonary metastases of 3LL cells in C57BL\/6 mice. However, depletion of NK cells alone by anti\u2010asialo GM1 (AGM1) antibody treatment did not increase the metastases in either organ. Interleukin\u201012 (IL\u201012) administration into mice induced strong cytotoxicities of NK cell\u2010depleted liver and lung mononuclear cells (MNC) comparable to those without NK\u2010cell depletion and inhibited metastases in either organ. In contrast, in both NK cell\u2010 and NK1<jats:sup>+<\/jats:sup> int T\u2010cell\u2010depleted mice, IL\u201012 could not induce cytotoxic activity of liver and lung MNC and metastases in both organs increased with or without IL\u201012 treatment. These results confirmed the fact that NK1<jats:sup>+<\/jats:sup> int T\u2003cells are more potent antitumour effectors than NK cells against experimental haematogenous tumour metastases.<\/jats:p>","DOI":"10.1046\/j.1365-2567.1997.00383.x","type":"journal-article","created":{"date-parts":[[2003,11,2]],"date-time":"2003-11-02T15:47:09Z","timestamp":1067788029000},"page":"561-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Antimetastatic effect of NK1<sup>+<\/sup> T\u2003cells on experimental haematogenous tumour metastases in the liver and lungs of mice"],"prefix":"10.1111","volume":"92","author":[{"given":"S.","family":"SEKI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"HASHIMOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"OGASAWARA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"SATOH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"WATANABE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"HABU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"HIRAIDE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"TAKEDA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,10,30]]},"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2567.1997.00383.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2567.1997.00383.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2567.1997.00383.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T06:51:36Z","timestamp":1694415096000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2567.1997.00383.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,12]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,12]]}},"alternative-id":["10.1046\/j.1365-2567.1997.00383.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2567.1997.00383.x","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,12]]},"assertion":[{"value":"2003-10-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}