{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:52:59Z","timestamp":1774140779848,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,10,31]],"date-time":"2003-10-31T00:00:00Z","timestamp":1067558400000},"content-version":"vor","delay-in-days":2343,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[1997,6]]},"abstract":"<jats:p>Infection of human epithelial cells by <jats:italic>Neisseria meningitidis<\/jats:italic> (MC) and <jats:italic>Neisseria gonorrhoeae<\/jats:italic> (GC) increases the rate of degradation of LAMP1, a major integral membrane glycoprotein of late endosomes and lysosomes. Several lines of evidence indicate that the neisserial IgA1 protease is directly responsible for this LAMP1 degradation. LAMP1 contains an IgA1\u2010like hinge region with potential cleavage sites for the neisserial type 1 and type 2 IgA1 proteases. Neisserial type 2 IgA1 protease cleaves purified LAMP1 <jats:italic>in vitro<\/jats:italic>. Unlike its wild\u2010type isogenic parent, an <jats:italic>iga<\/jats:italic><jats:sup>\u2212<\/jats:sup> mutant of <jats:italic>N. gonorrhoeae<\/jats:italic> cannot affect LAMP1 turnover and its growth in epithelial cells is dramatically reduced. Thus, IgA1 protease cleavage of LAMP1 promotes intracellular survival of pathogenic <jats:italic>Neisseria<\/jats:italic> spp.<\/jats:p>","DOI":"10.1046\/j.1365-2958.1997.4191776.x","type":"journal-article","created":{"date-parts":[[2003,11,2]],"date-time":"2003-11-02T17:49:29Z","timestamp":1067795369000},"page":"1083-1094","source":"Crossref","is-referenced-by-count":133,"title":["The <i>Neisseria<\/i> type 2 IgA1 protease cleaves LAMP1 and promotes survival of bacteria within epithelial cells"],"prefix":"10.1111","volume":"24","author":[{"given":"Lan","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Ayala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Larson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Mulks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven R.","family":"Carlsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Enns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalene","family":"So","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,10,31]]},"container-title":["Molecular Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1365-2958.1997.4191776.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2958.1997.4191776.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1365-2958.1997.4191776.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T04:04:48Z","timestamp":1694405088000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1365-2958.1997.4191776.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,6]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,6]]}},"alternative-id":["10.1046\/j.1365-2958.1997.4191776.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1365-2958.1997.4191776.x","archive":["Portico"],"relation":{},"ISSN":["0950-382X","1365-2958"],"issn-type":[{"value":"0950-382X","type":"print"},{"value":"1365-2958","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,6]]}}}