{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:37:37Z","timestamp":1774125457218,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,1,4]],"date-time":"2002-01-04T00:00:00Z","timestamp":1010102400000},"content-version":"vor","delay-in-days":1344,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:p> <jats:italic>Loss of T lymphocyte proliferation and the emergence of a host response that is dominated by a Th2\u2010type profile are well\u2010established features of human filarial infection. Downregulation and modulation of host T cell responses during lymphatic filariasis has been investigated by implantation of parasite stages into inbred mice. Adherent peritoneal exudate cells (PEC) from mice transplanted with adult or larval <\/jats:italic>Brugia malayi<jats:italic> parasites are profoundly anti\u2010proliferative but do not prevent antigen\u2010specific cytokine production by T cells. We demonstrate here that the excretory\/secretory (E\/S) products of the adult parasite are sufficient to induce PEC that block proliferation if injected daily into mice. We have previously shown that <\/jats:italic>in vivo<jats:italic> production of host IL\u20104 is required for the generation of suppressive cells. Because the induction of host IL\u20104 is characteristic of infection with nematodes, we asked whether E\/S from two other nematode parasites, <\/jats:italic>Nippostrongylus braziliensis<jats:italic> and <\/jats:italic>Toxocara canis<jats:italic> were also capable of generating a suppressor cell population. Injection of E\/S from these two parasites also led to a reduction in T cell proliferation suggesting that this mechanism of down\u2010regulating host responses is a feature common to nematode parasites<\/jats:italic>.<\/jats:p>","DOI":"10.1046\/j.1365-3024.1998.00151.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T17:08:00Z","timestamp":1047488880000},"page":"241-247","source":"Crossref","is-referenced-by-count":82,"title":["Profound suppression of cellular proliferation mediated by the secretions of nematodes"],"prefix":"10.1111","volume":"20","author":[{"given":"JUDITH E.","family":"ALLEN","sequence":"first","affiliation":[]},{"given":"ANDREW S.","family":"MACDONALD","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2002,1,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1128\/iai.63.8.2892-2898.1995","article-title":"Fine specificity of the genetically controlled immune response to native and recombinant gp15\/400 (polyprotein allergen) of Brugia malayi","volume":"63","author":"Allen J. 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