{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:18:41Z","timestamp":1768339121500,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,11,18]],"date-time":"2002-11-18T00:00:00Z","timestamp":1037577600000},"content-version":"vor","delay-in-days":1843,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold> Cerebral capillary sequestration and blood\u2010brain barrier (BBB) permeability to apolipoproteins E2 (apoE2), E3 (apoE3), and E4 (apoE4) and to their complexes with sA\u03b2<jats:sub>1\u201340<\/jats:sub>, a peptide homologous to the major form of soluble Alzheimer's amyloid \u03b2, were studied in perfused guinea pig brain. Cerebrovascular uptake of three apoE isoforms was low, their blood\u2010to\u2010brain transport undetectable, but uptake by the choroid plexus significant. Binding of all three isoforms to sA\u03b2<jats:sub>1\u201340<\/jats:sub> in vitro was similar with a <jats:italic>K<\/jats:italic><jats:sub>D<\/jats:sub> between 11.8 and 12.9 n<jats:italic>M<\/jats:italic>. Transport into brain parenchyma and sequestration by BBB and choroid plexus were negligible for sA\u03b2<jats:sub>1\u201340<\/jats:sub>\u2010apoE2 and sA\u03b2<jats:sub>1\u201340<\/jats:sub>\u2010apoE3, but significant for sA\u03b2<jats:sub>1\u201340<\/jats:sub>\u2010apoE4. After 10 min, 85% of sA\u03b2<jats:sub>1\u201340<\/jats:sub>\u2010apoE4 taken up at the BBB remained as intact complex, whereas free sA\u03b2<jats:sub>1\u201340<\/jats:sub> was 51% degraded. Circulating apoE isoforms have contrasting effects on cerebral capillary uptake of and BBB permeability of sA\u03b2. ApoE2 and apoE3 completely prevent cerebral capillary sequestration and blood\u2010to\u2010brain transport of sA\u03b2<jats:sub>1\u201340<\/jats:sub>. Conversely, apoE4, by entering brain microvessels and parenchyma as a stable complex with sA\u03b2, reduces peptide degradation and may predispose to cerebrovascular and possibly enhance parenchymal amyloid formation under pathological conditions.<\/jats:p>","DOI":"10.1046\/j.1471-4159.1997.69051995.x","type":"journal-article","created":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T03:21:26Z","timestamp":1279250486000},"page":"1995-2004","source":"Crossref","is-referenced-by-count":122,"title":["Isoform\u2010Specific Effects of Apolipoproteins E2, E3, and E4 on Cerebral Capillary Sequestration and Blood\u2010Brain Barrier Transport of Circulating Alzheimer's Amyloid \u03b2"],"prefix":"10.1111","volume":"69","author":[{"given":"Cynthia L.","family":"Martel","sequence":"first","affiliation":[]},{"given":"Jasmina B.","family":"Mackic","sequence":"additional","affiliation":[]},{"given":"Etsuro","family":"Matsubara","sequence":"additional","affiliation":[]},{"given":"Samuel","family":"Governale","sequence":"additional","affiliation":[]},{"given":"Calero","family":"Miguel","sequence":"additional","affiliation":[]},{"given":"Wesley","family":"Miao","sequence":"additional","affiliation":[]},{"given":"J. Gordon","family":"McComb","sequence":"additional","affiliation":[]},{"given":"Blas","family":"Frangione","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Ghiso","sequence":"additional","affiliation":[]},{"given":"Berislav V.","family":"Zlokovic","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2002,11,18]]},"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1471-4159.1997.69051995.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1471-4159.1997.69051995.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T09:42:33Z","timestamp":1698399753000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1471-4159.1997.69051995.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,11]]}},"alternative-id":["10.1046\/j.1471-4159.1997.69051995.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1471-4159.1997.69051995.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11]]}}}