{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:38:22Z","timestamp":1774867102681,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,11,14]],"date-time":"2002-11-14T00:00:00Z","timestamp":1037232000000},"content-version":"vor","delay-in-days":1747,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[1998,2]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold> Anandamide is an endogenous ligand of cannabinoid receptors that induces pharmacological responses in animals similar to those of cannabinoids such as \u0394<jats:sup>9<\/jats:sup>\u2010tetrahydrocannabinol (THC). Typical pharmacological effects of cannabinoids include disruption of pain, memory formation, and motor coordination, systems that all depend on NMDA receptor mediated neurotransmission. We investigated whether anandamide can influence NMDA receptor activity by examining NMDA\u2010induced calcium flux (\u0394Ca<jats:sup>2+<\/jats:sup><jats:sub>NMDA<\/jats:sub>) in rat brain slices. The presence of anandamide reduced \u0394Ca<jats:sup>2+<\/jats:sup><jats:sub>NMDA<\/jats:sub> and the inhibition was disrupted by cannabinoid receptor antagonist, pertussis toxin treatment, and agatoxin (a calcium channel inhibitor). Whereas these treatments prevented anandamide inhibiting \u0394Ca<jats:sup>2+<\/jats:sup><jats:sub>NMDA<\/jats:sub>, they also revealed another, underlying mechanism by which anandamide influences \u0394Ca<jats:sup>2+<\/jats:sup><jats:sub>NMDA<\/jats:sub>. In the presence of cannabinoid receptor antagonist, anandamide potentiated \u0394Ca<jats:sup>2+<\/jats:sup><jats:sub>NMDA<\/jats:sub> in cortical, cerebellar, and hippocampal slices. Anandamide (but not THC) also augmented NMDA\u2010stimulated currents in <jats:italic>Xenopus<\/jats:italic> oocytes expressing cloned NMDA receptors, suggesting a capacity to directly modulate NMDA receptor activity. In a similar manner, anandamide enhanced neurotransmission across NMDA receptor\u2010dependent synapses in hippocampus in a manner that was not mimicked by THC and was unaffected by cannabinoid receptor antagonist. These data demonstrate that anandamide can modulate NMDA receptor activity in addition to its role as a cannabinoid receptor ligand.<\/jats:p>","DOI":"10.1046\/j.1471-4159.1998.70020671.x","type":"journal-article","created":{"date-parts":[[2010,7,15]],"date-time":"2010-07-15T22:12:26Z","timestamp":1279231946000},"page":"671-676","source":"Crossref","is-referenced-by-count":166,"title":["Dual Effects of Anandamide on NMDA Receptor\u2010Mediated Responses and Neurotransmission"],"prefix":"10.1111","volume":"70","author":[{"given":"Aidan J.","family":"Hampson","sequence":"first","affiliation":[]},{"given":"Lester M.","family":"Bornheim","sequence":"additional","affiliation":[]},{"given":"Massimo","family":"Scanziani","sequence":"additional","affiliation":[]},{"given":"C. Spencer","family":"Yost","sequence":"additional","affiliation":[]},{"given":"Andrew T.","family":"Gray","sequence":"additional","affiliation":[]},{"given":"Bonnie M.","family":"Hansen","sequence":"additional","affiliation":[]},{"given":"Dmitri J.","family":"Leonoudakis","sequence":"additional","affiliation":[]},{"given":"Philip E.","family":"Bickler","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2002,11,14]]},"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1471-4159.1998.70020671.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1471-4159.1998.70020671.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T17:23:02Z","timestamp":1698513782000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1471-4159.1998.70020671.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,2]]}},"alternative-id":["10.1046\/j.1471-4159.1998.70020671.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1471-4159.1998.70020671.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,2]]}}}