{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:41:45Z","timestamp":1774867305897,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,11,14]],"date-time":"2002-11-14T00:00:00Z","timestamp":1037232000000},"content-version":"vor","delay-in-days":1719,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[1998,3]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold> \u03b2\u2010Amyloid peptides (A\u03b2) are deposited in an aggregated fibrillar form in both diffuse and senile plaques in the brains of patients with Alzheimer's disease. The neurotoxicity of A\u03b2 in cultured neurons is dependent on its aggregation state, but the factors contributing to aggregation and fibril formation are poorly understood. In the present study, we investigated whether \u03b1<jats:sub>2<\/jats:sub>\u2010macroglobulin (\u03b1<jats:sub>2<\/jats:sub>M), a protein present in neuritic plaques and elevated in Alzheimer's disease brain, is a potential regulatory factor for A\u03b2 fibril formation. Previous studies in our laboratory have shown that \u03b1<jats:sub>2<\/jats:sub>M is an A\u03b2 binding protein. We now report that, in contrast to another plaque\u2010associated protein, \u03b1<jats:sub>1<\/jats:sub>\u2010antichymotrypsin, \u03b1<jats:sub>2<\/jats:sub>M coincubated with A\u03b2 significantly reduces aggregation and fibril formation in vitro. Additionally, cultured fetal rat cortical neurons are less vulnerable to the toxic actions of aged A\u03b2 following pretreatment with \u03b1<jats:sub>2<\/jats:sub>M. We postulate that \u03b1<jats:sub>2<\/jats:sub>M is able to maintain A\u03b2 in a soluble state, preventing fibril formation and associated neurotoxicity.<\/jats:p>","DOI":"10.1046\/j.1471-4159.1998.70031182.x","type":"journal-article","created":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T03:01:31Z","timestamp":1279249291000},"page":"1182-1188","source":"Crossref","is-referenced-by-count":88,"title":["\u03b1<sub>2<\/sub>\u2010Macroglobulin Attenuates \u03b2\u2010Amyloid Peptide 1\u201340 Fibril Formation and Associated Neurotoxicity of Cultured Fetal Rat Cortical Neurons"],"prefix":"10.1111","volume":"70","author":[{"given":"Yansheng","family":"Du","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly R.","family":"Bales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard C.","family":"Dodel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele A.","family":"Glinn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey W.","family":"Horn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila P.","family":"Little","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,11,14]]},"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1471-4159.1998.70031182.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1471-4159.1998.70031182.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T08:32:34Z","timestamp":1698481954000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1471-4159.1998.70031182.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["10.1046\/j.1471-4159.1998.70031182.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1471-4159.1998.70031182.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,3]]}}}