{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:53:44Z","timestamp":1762113224400},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,11,14]],"date-time":"2002-11-14T00:00:00Z","timestamp":1037232000000},"content-version":"vor","delay-in-days":1688,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[1998,4]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold> The frequency of the \u03b54 allele of apolipoprotein E(apoE) is increased in late\u2010onset and sporadic forms of Alzheimer's disease (AD). ApoE also binds to \u03b2\u2010amyloid (A\u03b2) and both proteins are found in AD plaques. To further investigate the potential interaction of apoE and A\u03b2 in the pathogenesis of AD, we have determined the binding, internalization, and degradation of human apoE isoforms in the presence and absence of A\u03b2 peptides to rat primary hippocampal neurons. We demonstrate that the lipophilic A\u03b2 peptides, in particular A\u03b2<jats:sub>1\u201342<\/jats:sub>, A\u03b2<jats:sub>1\u201340<\/jats:sub>, and A\u03b2<jats:sub>25\u201335<\/jats:sub>, increase significantly apoE\u2010liposome binding to hippocampal neurons. For each A\u03b2 peptide, the increase was significantly greater for the apoE4 isoform than for the apoE3 isoform. The most effective of the A\u03b2 peptides to increase apoE binding, A\u03b2<jats:sub>25\u201335<\/jats:sub>, was further shown to increase significantly the internalization of both apoE3\u2010 and apoE4\u2010liposomes, without affecting apoE degradation. Conversely, A\u03b2<jats:sub>1\u201340<\/jats:sub> uptake by hippocampal neurons was shown to be increased in the presence of apoE\u2010liposomes, more so in the presence of the apoE4 than the apoE3 isoform. These results provide evidence that A\u03b2 peptides interact directly with apoE lipoproteins, which may then be transported together into neuronal cells through apoE receptors.<\/jats:p>","DOI":"10.1046\/j.1471-4159.1998.70041458.x","type":"journal-article","created":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T02:42:17Z","timestamp":1279248137000},"page":"1458-1466","source":"Crossref","is-referenced-by-count":58,"title":["\u03b2\u2010Amyloid Peptides Increase the Binding and Internalization of Apolipoprotein E to Hippocampal Neurons"],"prefix":"10.1111","volume":"70","author":[{"given":"Uwe","family":"Beffert","sequence":"first","affiliation":[]},{"given":"Nicole","family":"Aumont","sequence":"additional","affiliation":[]},{"given":"Doris","family":"Dea","sequence":"additional","affiliation":[]},{"given":"Suzanne","family":"Lussier\u2010Cacan","sequence":"additional","affiliation":[]},{"given":"Jean","family":"Davignon","sequence":"additional","affiliation":[]},{"given":"Judes","family":"Poirier","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2002,11,14]]},"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1471-4159.1998.70041458.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1471-4159.1998.70041458.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T07:02:42Z","timestamp":1698476562000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1471-4159.1998.70041458.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,4]]}},"alternative-id":["10.1046\/j.1471-4159.1998.70041458.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1471-4159.1998.70041458.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,4]]}}}