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In contemporary healthcare, telehealth has gained recognition as an effective approach for managing chronic illnesses by improving equitable access to quality medical services and minimising expenses. The purpose of this systematic review is to evaluate the role of telehealth in enhancing the well\u2010being of patients with Alzheimer's disease and supporting their caregivers, as evidenced by findings from randomised controlled trials (RCTs). This systematic review concentrated on RCTs published in English, with no constraints on publication date. The search process was accomplished on 11 August, 2025, using appropriate keywords across well\u2010established scientific databases, including PubMed, Embase, Scopus, ScienceDirect, Web of Science and ProQuest. The quality of the studies was assessed using the Joanna Briggs Institute checklist and only those scoring above seven were included in the analysis. From an initial collection of 1242 articles, 14 trials were ultimately included in this review. Telehealth interventions demonstrated significant improvements in cognitive function, mobility and quality of life among individuals with mild cognitive impairment and Alzheimer's Disease, while also reducing caregiver burden and psychological distress. These interventions, implemented through synchronous and asynchronous delivery methods, were deemed feasible, well\u2010received and associated with strong adherence rates. Nonetheless, limitations such as small sample sizes and restricted access to technological resources emphasise the need for additional research to address these gaps. The findings from 13 out of 14 articles in this systematic review indicate that telehealth interventions, including virtual reality, video conferencing, computerised cognitive training and group movement programs, have the potential to significantly enhance health outcomes and quality of life for individuals with Alzheimer's disease and their caregivers compared to traditional in\u2010person treatments. These interventions, delivered through diverse and flexible modalities, also demonstrate cost\u2010effectiveness and improved caregiver well\u2010being, reinforcing telehealth as a scalable and effective approach for comprehensive Alzheimer's care.<\/jats:p>","DOI":"10.1049\/htl2.70065","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T05:00:04Z","timestamp":1770786004000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Effect of Telehealth on Alzheimer's Disease, Dementia and Mild Cognitive Impairment: A Systematic Review of Clinical Trials"],"prefix":"10.1049","volume":"13","author":[{"given":"Kosar","family":"Ghaddaripouri","sequence":"first","affiliation":[{"name":"Department of Health Information Management School of Health Management and Information Sciences Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Student Research Committee Shiraz University of 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