{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:01:13Z","timestamp":1793145673989,"version":"4.5.0"},"reference-count":24,"publisher":"Institution of Engineering and Technology (IET)","issue":"3","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IET Nanobiotechnology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>\n                    Recently, the authors reported newly synthesised polyethylene glycol (PEG)ylated silver (9%)\u2010doped zinc oxide nanoparticle (doped semiconductor nanoparticle (DSN)) which has high potency for killing\n                    <jats:italic>Leishmania tropica<\/jats:italic>\n                    by producing reactive oxygen species on exposure to sunlight. The current report is focused on\n                    <jats:italic>Leishmania<\/jats:italic>\n                    DNA interaction and damage caused by the DSN. Here, we showed that the damage to\n                    <jats:italic>Leishmania<\/jats:italic>\n                    DNA was indirect, as the DSN was unable to interact with the DNA in intact\n                    <jats:italic>Leishmania<\/jats:italic>\n                    cell, indicating the incapability of PEGylated DSN to cross the nucleus barrier. The DNA damage was the result of high production of singlet oxygen on exposure to sunlight. The DNA damage was successfully prevented by singlet oxygen scavenger (sodium azide) confirming involvement of the highly energetic singlet oxygen in the DNA degradation process.\n                  <\/jats:p>","DOI":"10.1049\/iet-nbt.2015.0015","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T08:09:31Z","timestamp":1445933371000},"page":"129-133","source":"Crossref","is-referenced-by-count":22,"title":["Photo\u2010induced\n                    <i>Leishmania<\/i>\n                    DNA degradation by silver\u2010doped zinc oxide nanoparticle: an\n                    <i>in\u2010vitro<\/i>\n                    approach"],"prefix":"10.1049","volume":"10","author":[{"given":"Akhtar","family":"Nadhman","sequence":"first","affiliation":[{"name":"Department of Biotechnology Quaid\u2010i\u2010Azam University Islamabad Pakistan"},{"name":"Nanosciences and Catalysis Division National Centre for physics Shahdra Valley Road, Quaid\u2010i\u2010Azam University campus Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Sirajuddin","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Science &amp; Technology Bannu Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samina","family":"Nazir","sequence":"additional","affiliation":[{"name":"Nanosciences and Catalysis Division National Centre for physics Shahdra Valley Road, Quaid\u2010i\u2010Azam University campus Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoom","family":"Yasinzai","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Quaid\u2010i\u2010Azam University Islamabad Pakistan"},{"name":"Center of Interdisciplinary Research International Islamic University Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"265","published-online":{"date-parts":[[2016,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2012.03.007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/b818081d"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2008.02.015"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709501105"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr960421s"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.01.008"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200801220"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.20661"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/25\/13\/135101"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.13.143"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(93)90181-E"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2012.03.068"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2014.06.099"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(88)90265-0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.09.005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-012-0705-6"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(97)00126-3"},{"issue":"9","key":"e_1_2_6_19_1","article-title":"Singlet oxygen mediated DNA degradation by copper nanoparticles: potential towards cytotoxic effect on cancer cells","volume":"9","author":"Jose G.P.","year":"2011","journal-title":"J. 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