{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T03:38:15Z","timestamp":1772941095433,"version":"3.50.1"},"reference-count":57,"publisher":"Institution of Engineering and Technology (IET)","issue":"6","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IET Nanobiotechnology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>\n                    Tea polyphenols (TPPs) comprise preventive and therapeutic potentials against cancer, cardiovascular and neurological disorders. Chemical instability of TPP which leads to low bioavailability is the major constrain to its use as therapeutic agent. The authors prepared TPP encapsulated solid lipid nanoparticles (TPP\u2010SLNs) to increase its stability and bioefficacy. Comparison of Fourier transformed infrared spectra of unloaded SLN, free TPP and TPP\u2010SLN indicated encapsulation of TPP. Sustained release of TPP from TP\u2010SLN was observed. TPP\u2010SLN showed prolonged free radical scavenging activity compared with free TPP indicating protection of TPP. TPP\u2010SLN showed activation of Caspases\u20109 and \u20103 cascades in breast cancer cell line (Michigan cancer foundation (MCF)\u20107) at\n                    <jats:italic>in vitro<\/jats:italic>\n                    conditions. Biochemical parameters were altered in Ehrlich ascetic carcinoma (EAC) cell bearing mice compared with normal (uninduced) mice which were ameliorated significantly by oral feeding of TPP\u2010SLN. Oral administration (pre\u2010 and post\u2010treated) of TPP\u2010SLN in EAC bearing mice resulted in significant increase of plasma haemoglobin, glucose, superoxide dismutase and catalase when compared with EAC bearing control mice. Other biochemical parameters (cholesterol, bilirubin, triglyceride, urea, total protein, alanine aminotransferase, alkaline phosphatase and aspertate transaminase were significantly decreased on oral administration (pre\u2010 and post\u2010treated) of TPP\u2010SLN in EAC bearing mice.\n                  <\/jats:p>","DOI":"10.1049\/iet-nbt.2015.0113","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T16:25:17Z","timestamp":1459355117000},"page":"419-424","source":"Crossref","is-referenced-by-count":15,"title":["Positive regulation of biochemical parameters by tea polyphenol encapsulated solid lipid nanoparticles at\n                    <i>in vitro<\/i>\n                    and\n                    <i>in vivo<\/i>\n                    conditions"],"prefix":"10.1049","volume":"10","author":[{"given":"Karikalan","family":"Kulandaivelu","sequence":"first","affiliation":[{"name":"School of Bio Sciences and Technology VIT University Vellore 632014 Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abul Kalam Azad","family":"Mandal","sequence":"additional","affiliation":[{"name":"School of Bio Sciences and Technology VIT University Vellore 632014 Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"265","published-online":{"date-parts":[[2016,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"221","article-title":"Tea in chemoprevention of cancer: epidemiologic and experimental studies","volume":"8","author":"Katiyar S.K.","year":"1996","journal-title":"Int. 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