{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:57:09Z","timestamp":1790697429655,"version":"4.1.0"},"reference-count":42,"publisher":"Institution of Engineering and Technology (IET)","issue":"4","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IET Nanobiotechnology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>\n                    The main goal of this study was to synthesise and characterise different formulations based on alginate and alginate\/chitosan microspheres containing nanoselenium (nano\u2010Se) for controlled delivery applications. Nanosize elemental selenium was produced by using probiotic yogurt bacteria (\n                    <jats:italic>Lactobacillus casei<\/jats:italic>\n                    ) in a fermentation procedure. The structural and morphological characterisation of the microspheres was performed by Fourier transform infrared (FTIR), X\u2010ray diffraction (XRD) and scanning electron microscopy (SEM) analysis. FTIR and XRD pattern indicated that was an effective cross\u2010linking of selenium nanoparticles within the polymeric matrix in both cases. The SEM images reveal that selenium nanoparticles are mainly exposed on the surface of alginate, in contrast to porous structure of alginate\/chitosan\/nano\u2010Se, interconnected in a regular network. This architecture type has a considerable importance in the delivery process, as demonstrated by differential pulse voltammetry. Selenium release from both matrices is pH sensitive. Moreover, chitosan blended with alginate minimise the release of encapsulated selenium, in simulated gastric fluid, and prolong the duration of release in intestinal fluid. The overall effect is the enhancement of total percentage release concomitant with the longer duration of action. The authors\u2019 formulation based on alginate\/chitosan is a convenient matrix to be used for selenium delivery in duodenum, caecum and colon.\n                  <\/jats:p>","DOI":"10.1049\/iet-nbt.2016.0107","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T07:06:14Z","timestamp":1476947174000},"page":"426-432","source":"Crossref","is-referenced-by-count":38,"title":["Preparation, structural characterisation and release study of novel hybrid microspheres entrapping nanoselenium, produced by green synthesis"],"prefix":"10.1049","volume":"11","author":[{"given":"Simona","family":"Cavalu","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Pharmacy University of Oradea P\u2010ta 1 Decembrie 10 410087 Oradea Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u03ccszef","family":"Prokisch","sequence":"additional","affiliation":[{"name":"Institute of Bio\u2010 and Environmental Energetics, Debrecen University Boszormenyi Utca 138 Debrecen 4032 Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasile","family":"Laslo","sequence":"additional","affiliation":[{"name":"Faculty of Environmental Protection University of Oradea 26 Gen. 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