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Its low solubility in water and chemical decomposition in intestinal environment are predicaments in delivery through dietary or oral intake. Noble polymeric nanoparticles are of particular interest today because of their applications in many areas. Polymer nanoparticles have attracted the interest of many research groups and have been utilised in an increasing number of fields such as site targeted drug delivery in cancer research during the last decades. Various techniques can be used to produce polymer nanoparticles, such as solvent evaporation, salting\u2010out, dialysis, supercritical fluid technology etc. The choice of method depends on a number of factors, such as, particle size, particle size distribution, area of application, etc. In the present study, single emulsion\u2010solvent evaporation technique has been utilised with two different organic solvents: acetone and chloroform\/methanol to prepare quercetin loaded poly(D,L\u2010lactide\u2010co\u2010glycolide) nanoparticles. According to the authors\u2019 observations acetone is a better solvent for encapsulating quercetin in polymer nanoparticles owing to its physical and chemical properties.<\/jats:p>","DOI":"10.1049\/iet-nbt.2016.0116","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T03:05:55Z","timestamp":1477019155000},"page":"443-447","source":"Crossref","is-referenced-by-count":12,"title":["Solvent effect in the synthesis of hydrophobic drug\u2010loaded polymer nanoparticles"],"prefix":"10.1049","volume":"11","author":[{"given":"Sandip","family":"Pal","sequence":"first","affiliation":[{"name":"Department of Biotechnology Maulana Abul Kalam Azad University of Technology Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chabita","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Maulana Abul Kalam Azad University of Technology Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"265","published-online":{"date-parts":[[2017,3,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.01.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2003.12.005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf050061m"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(95)00077-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20325"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(03)00529-6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(95)93575-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(97)00240-X"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr940351u"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00115-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(00)00339-4"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-0286(02)00117-1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2004.11.027"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(94)00324-X"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(97)00048-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(02)00228-4"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(91)90314-E"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-3659(93)90103-C"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-6865(95)00059-3"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(95)04369-1"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(98)00185-0"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/jcis.1996.4637"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(99)00187-8"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200901158"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.01.054"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1556-276X-9-684"}],"container-title":["IET Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1049\/iet-nbt.2016.0116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1049\/iet-nbt.2016.0116","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ietresearch.onlinelibrary.wiley.com\/doi\/pdf\/10.1049\/iet-nbt.2016.0116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:09:22Z","timestamp":1761674962000},"score":1,"resource":{"primary":{"URL":"https:\/\/ietresearch.onlinelibrary.wiley.com\/doi\/10.1049\/iet-nbt.2016.0116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,3]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1049\/iet-nbt.2016.0116"],"URL":"https:\/\/doi.org\/10.1049\/iet-nbt.2016.0116","archive":["Portico"],"relation":{},"ISSN":["1751-8741"],"issn-type":[{"value":"1751-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3,3]]}}}