{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:25:38Z","timestamp":1789647938531,"version":"4.0.0"},"reference-count":32,"publisher":"Institution of Engineering and Technology (IET)","issue":"5","license":[{"start":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T00:00:00Z","timestamp":1498694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IET Nanobiotechnology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>\n                    Foley catheters are inevitable in health care unit. Pathogens colonise and form biofilm on catheter causing catheter\u2010associated urinary tract infection. Therefore, the authors aimed to functionalise catheter to resist biofilm formation. The authors impregnated urinary catheters with a synergistic combination of antibiotics and silver nanoparticles (SNPs) to evaluate antibiofilm efficacy\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . SNPs were synthesised using\n                    <jats:italic>Spirulina platensis<\/jats:italic>\n                    . Synergy between the SNPs and antibiotics was determined by the checker\u2010board method.\n                    <jats:italic>In vivo<\/jats:italic>\n                    efficacy of the functionalised catheters was assessed in mice. Liver and kidney function tests of mice were performed. The\n                    <jats:italic>in vitro<\/jats:italic>\n                    anti\u2010adherence activity of the functionalised catheters was evaluated after 2 years. Nanoparticle sizes were 42\u201375\u00a0nm. Synergistic activity was observed among SNPs (2 \u00b5g\/ml), amikacin (6.25 \u00b5g\/ml), and nitrofurantoin (31.25 \u00b5g\/ml). In mice, catheters functionalised with combinations of antibiotics and SNPs exhibited no colonisation until Day 14. Blood, liver, and kidney tests were normal. After 2 years, catheters functionalised with antibiotics exhibited 25% inhibition of bacterial adhesion, and catheters functionalised with the nanoparticle\u2010antibiotic combination exhibited 90% inhibition. Impregnation of urinary catheters with a synergistic combination of antibiotics and SNPs is an efficient and promising method for preventing biofilm formation.\n                  <\/jats:p>","DOI":"10.1049\/iet-nbt.2016.0148","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T21:18:05Z","timestamp":1485811085000},"page":"612-620","source":"Crossref","is-referenced-by-count":39,"title":["Foley catheters functionalised with a synergistic combination of antibiotics and silver nanoparticles resist biofilm formation"],"prefix":"10.1049","volume":"11","author":[{"given":"Rajendran","family":"Mala","sequence":"first","affiliation":[{"name":"Department of Biotechnology Mepco Schlenk Engineering College Sivakasi 626005 Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony","family":"Annie Aglin","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Mepco Schlenk Engineering College Sivakasi 626005 Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arul Selvaraj","family":"Ruby Celsia","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Mepco Schlenk Engineering College Sivakasi 626005 Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivalingam","family":"Geerthika","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Mepco Schlenk Engineering College Sivakasi 626005 Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narbahvi","family":"Kiruthika","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Mepco Schlenk Engineering College Sivakasi 626005 Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinnathambi","family":"VazagaPriya","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Mepco Schlenk Engineering College Sivakasi 626005 Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumarapillai","family":"Srinivasa Kumar","sequence":"additional","affiliation":[{"name":"Inbiotics Clinical Research Laboratory Nagercoil 629001 Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"265","published-online":{"date-parts":[[2017,6,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-012-0930-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-014-6128-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33491"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-013-4870-0"},{"key":"e_1_2_6_6_1","first-page":"1175","article-title":"Antibiofilm surface functionalization of catheters by magnesium fluoride nanoparticles","volume":"7","author":"Lellouche J.","year":"2012","journal-title":"Int. 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