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Furthermore, folic acid (FA) and methotrexate (MTX) through ethylenediamine (ED) were attached to the surface of f\u2010MWCNT to synthesise MWCNT\u2013ED\u2013FA and MWCNT\u2013ED\u2013MTX. Release studies of MTX as free drug and in MWCNT\u2013ED\u2013MTX were performed. These studies showed that MTX release rate from MWCNT\u2013ED\u2013MTX decreased in comparison with free MTX, which is due to the MTX attachment on the MWCNT. The anticancer effect of MWCNT\u2013ED\u2013FA and MWCNT\u2013ED\u2013MTX on the breast cancer cell line (MCF\u20107) was studied. Studies have shown that MWCNT\u2013ED\u2013MTX cytotoxicity is more than that of MWCNT\u2013ED\u2013FA, which is due to the presence of MTX. Furthermore, the anticancer effects of MWCNT\u2013ED\u2013FA and MWCNT\u2013ED\u2013MTX in the presence of infrared laser radiation on the MCF7 cell were studied. The experiments showed that in the presence of the laser, the cytotoxicities of MWCNT\u2013ED\u2013FA and MWCNT\u2013ED\u2013MTX were the same and increased in comparison with laser absence, which indicates that the photothermal effect is stronger than other factors and mask their effects. This effect can be related to laser radiation absorption by MWCNT and its conversion to heat which can induce cancer cell death. Targeting studies have shown that MWCNT\u2013ED\u2013FA is targeted to the cancer cells due to the presence of FA.<\/jats:p>","DOI":"10.1049\/iet-nbt.2018.5085","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T22:40:35Z","timestamp":1535668835000},"page":"52-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Functionalisation of carbon nanotubes by methotrexate and study of synchronous photothermal effect of carbon nanotube and anticancer drug on cancer cell death"],"prefix":"10.1049","volume":"13","author":[{"given":"Ali","family":"Karimi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics School of Pharmacy Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Erfan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics School of Pharmacy Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Alireza","family":"Mortazavi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics School of Pharmacy Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Ghorbani\u2010Bidkorbeh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics School of Pharmacy Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzad","family":"Kobarfard","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry School of Pharmacy Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farshad H.","family":"Shirazi","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Pharmacology School of Pharmacy Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"265","published-online":{"date-parts":[[2018,10,24]]},"reference":[{"issue":"3","key":"e_1_2_6_2_1","first-page":"168","article-title":"Understanding the mechanisms of action of methotrexate","volume":"65","author":"Tian H.","year":"2007","journal-title":"Bull. 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