{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T23:35:20Z","timestamp":1774049720439,"version":"3.50.1"},"reference-count":30,"publisher":"Institution of Engineering and Technology (IET)","issue":"4","license":[{"start":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T00:00:00Z","timestamp":1555459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ietresearch.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IET Nanobiotechnology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>\n                    Chondrosarcoma is the second\u2010most malignant cancer of the bone and routine treatments such as chemotherapy and radiotherapy have not responded to the treatment of this cancer. Due to the resistance of chondrosarcoma to radiotherapy, the combination of therapeutic methods has been considered in recent years. In this study, a novel combination approach is used that allows photodynamic therapy to be activated by X\u2010rays. The synthesis of Mn\u2010doped zinc sulphide (ZnS) quantum dots was carried out and chlorin e6\u00a0photosensitiser attached by covalent and non\u2010covalent methods and their application as an intracellular light source for photodynamic activation was investigated. The toxicity of each nanoparticles was evaluated on chondrosarcoma cancer cells (SW1353) before and after radiation. Also, the effect nanoparticle\u2010photosensitiser conjugated type was investigated in the therapeutic efficacy. The characterisation test (SEM, TEM, EDS, TGA, XRD and ICP analyses) was shown successful synthesis of Mn\u2010doped ZnS quantum dots. Chondrosarcoma cancer cell viability was significantly reduced when cells were treated with MPA\u2010capped Mn\u2010doped ZnS quantum dots\u2010chlorin e6 with spermine linker and with covalent attachment (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009\u2264\u20090.001). These results indicate that X\u2010ray can activate the quantum dot complexes for cancer treatment, which can be a novel method for treatment of chondrosarcoma.\n                  <\/jats:p>","DOI":"10.1049\/iet-nbt.2018.5387","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T21:42:47Z","timestamp":1548798167000},"page":"387-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Mn\u2010doped ZnS quantum dots\u2010chlorin e6 shows potential as a treatment for chondrosarcoma: an in vitro study"],"prefix":"10.1049","volume":"13","author":[{"given":"Neda Baradaran","family":"Mohsenian","sequence":"first","affiliation":[{"name":"Department of Medical Physics School of Medicine, Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Shanei","sequence":"additional","affiliation":[{"name":"Department of Medical Physics School of Medicine, Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Jamal","family":"Alavi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Sciences School of Paramedical Sciences, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Kheirollahi","sequence":"additional","affiliation":[{"name":"Department of Genetic and Molecular Biology School of Medicine, Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azadeh Hashem","family":"Nia","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Center School of Pharmacy, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad Bagher","family":"Tavakoli","sequence":"additional","affiliation":[{"name":"Department of Medical Physics School of Medicine, Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"265","published-online":{"date-parts":[[2019,4,17]]},"reference":[{"issue":"3","key":"e_1_2_6_2_1","first-page":"43","article-title":"Chondrosarcoma, a 30 year retrospective study in cancer institute Imam Khomeini hospital and faculty of dentistry of Tehran University of medical sciences","volume":"1","author":"Eshghyar N.","year":"2004","journal-title":"J. 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