{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T17:28:03Z","timestamp":1784568483820,"version":"3.55.0"},"reference-count":48,"publisher":"Institution of Engineering and Technology (IET)","issue":"8","license":[{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ietresearch.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IET Nanobiotechnology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Age\u2010related macular degeneration (AMD) is a disease affecting the macula by the new blood vessels formation. AMD is widely treated with a combination of anti\u2010angiogenic and anti\u2010vascular endothelial growth factor (VEGF) agents. The topical administration of nanodispersions showed enhanced ocular residence time with controlled and prolonged drug delivery to the disease site at the back of the eye. In the present study we developed and characterized nanodispersion containing anti\u2010angiogenic (artemisinin) and anti\u2010VEGF agent (dexamethasone) for the topical ocular administration in order to obtain a required drug concentration in the posterior part of the eye. The nanodispersions were prepared with varying concentration of polymer, polyvinyl pyrrolidone K90 and polymeric surfactant, Poloxamer 407. The nanodispersions were found to be smooth and spherical in shape with a size range of 12\u201326 nm. In\u2010vitro drug release studies showed the 90\u2013101% of artemisinin and 55\u2013103% of dexamethasone release from the nanodispersions. The blank formulation with a high concentration of polymer and polymeric surfactant showed an acceptable level of haemolysis and DNA damage. The chorioallantoic membrane assay suggested that the nanodispersion possess good anti\u2010angiogenic effect. Hence the formulated artemisinin and dexamethasone nanodispersion may have the great potential for the AMD treatment.<\/jats:p>","DOI":"10.1049\/iet-nbt.2019.0130","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T22:55:18Z","timestamp":1564440918000},"page":"868-874","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Design and development of artemisinin and dexamethasone loaded topical nanodispersion for the effective treatment of age\u2010related macular degeneration"],"prefix":"10.1049","volume":"13","author":[{"given":"Chandrasekar","family":"Ponnusamy","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology Bharathidasan Institute of Technology, Anna University Tiruchirappalli Tamilnadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2321-9876","authenticated-orcid":false,"given":"Abimanyu","family":"Sugumaran","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics SRM Institute of Science and Technology SRM Nagar Kattankulathur Tamilnadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkateshwaran","family":"Krishnaswami","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology Bharathidasan Institute of Technology, Anna University Tiruchirappalli Tamilnadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruckmani","family":"Kandasamy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology Bharathidasan Institute of Technology, Anna University Tiruchirappalli Tamilnadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramanian","family":"Natesan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology Bharathidasan Institute of Technology, Anna University Tiruchirappalli Tamilnadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"265","published-online":{"date-parts":[[2019,9,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1076\/opep.11.2.67.28158"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c981"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-4182(05)80070-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.4.564"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.10.007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890600946724"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2008.10.001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.6.7.717"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1984.01040031330019"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062655"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1135"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107680409700403"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.06.039"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000252658"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/247597"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules15031705"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.06.023"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1208\/aapsj070122"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1984-82502009000100010"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.12.015"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(02)00468-5"},{"key":"e_1_2_6_23_1","first-page":"49","article-title":"Triple\u2010combination therapy in the treatment of CNV due to AMD","author":"Augustin A.J.","year":"2008","journal-title":"Retina Today"},{"key":"e_1_2_6_24_1","first-page":"79","article-title":"Determination of dexamethasone sodium phosphate in the vitreous by high performance liquid chromatography, Korean","volume":"9","author":"Kwak H.W.","year":"1995","journal-title":"J. Ophthalmol."},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2007.09.003"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-010-9183-3"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.1.1.99"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0954"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.3.2.275"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.12.018"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2010.08.002"},{"key":"e_1_2_6_32_1","first-page":"346","article-title":"Enhancing solubility and dissolution of celecoxib by spray drying using pluronic F 127","volume":"45","author":"Dixit M.","year":"2011","journal-title":"Indian J. Pharm. Res. Educ."},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.4103\/2231-4040.79799"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2007.05.009"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/157341291001140102111031"},{"key":"e_1_2_6_36_1","first-page":"11","article-title":"Permeation through cornea","volume":"39","author":"Malhotra M.","year":"2001","journal-title":"Indian. J. Exp. Biol."},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-010-0237-0"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00215533"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20627"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(02)00025-6"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.12.007"},{"key":"e_1_2_6_42_1","first-page":"934","article-title":"Comparison of crystalline and amorphous carriers to improve the dissolution profile of water insoluble drug itraconazole","volume":"4","author":"Garg A.K.","year":"2013","journal-title":"Int. J. Pharma Biol. Sci."},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10007-009-0037-4"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2010.2984"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2006.673"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(02)00234-X"},{"key":"e_1_2_6_47_1","first-page":"693","article-title":"Characterization and evaluation of curcumin\u2010PVP solid dispersion by solvent evaporation technique","volume":"2","author":"Kumavat S.D.","year":"2013","journal-title":"Int. J. Pharma. Res. Sci."},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717540902850567"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-008-9729-6"}],"container-title":["IET Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1049\/iet-nbt.2019.0130","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1049\/iet-nbt.2019.0130","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ietresearch.onlinelibrary.wiley.com\/doi\/pdf\/10.1049\/iet-nbt.2019.0130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:55:13Z","timestamp":1761677713000},"score":1,"resource":{"primary":{"URL":"https:\/\/ietresearch.onlinelibrary.wiley.com\/doi\/10.1049\/iet-nbt.2019.0130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,20]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1049\/iet-nbt.2019.0130"],"URL":"https:\/\/doi.org\/10.1049\/iet-nbt.2019.0130","archive":["Portico"],"relation":{},"ISSN":["1751-8741"],"issn-type":[{"value":"1751-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9,20]]},"assertion":[{"value":"2019-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}