{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T12:31:56Z","timestamp":1784723516416,"version":"3.55.0"},"reference-count":46,"publisher":"Institution of Engineering and Technology (IET)","issue":"1","license":[{"start":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:00:00Z","timestamp":1576454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ietresearch.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IET Nanobiotechnology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>\n                    Magnetic manotheranostics can be a fascinating charm to diagnose a tumour with MRI, and treatment through hyperthermia. This study aims to synthesise and characterise magnetically responsive polymer colloids (MRPCs). Healthy tissue damage done by chemotherapy session could be minimised by MRPCs. For the colloidal formulation of MRPCs, the oil in water emulsion technique was employed with the aid of sonication and stirring. The organic phase of emulsion contained methotrexate (MTX) drug, Eudragit E100 and CoFe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    (synthesised by co\u2010precipitation) in ethanol, and the aqueous phase contained tween 80\u00a0in deionised water. The emulsion was optimised by studying\/adjusting two different parameters, i.e. the concentration of constituents and sonication cycles. Multiple formulations were produced at sonication amplitude of 60% at 20\u00a0kHz, followed by centrifugation and lyophilisation. Characterisation of MRPCs was done for morphology, size measurement (23\u201325\u00a0nm), surface charge (\u223c15.12), coercivity (\u223c1549.6 G), magnetisation (2.6 emu) and retentivity (1.34 emu). Drug release in simulating physiological environment (pH\u2009=\u20097.4), was observed for up to 48 h, and, to determine the best release kinetic mechanism results were compared with kinetic models. Magnetic hyperthermia studies showed that MRPCs achieved an acceptable temperature of 42\u00b0C, for hyperthermia treatments in cancer patients.\n                  <\/jats:p>","DOI":"10.1049\/iet-nbt.2019.0148","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T22:35:45Z","timestamp":1570487745000},"page":"33-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Co\u2010encapsulating CoFe\n                    <sub>2<\/sub>\n                    O\n                    <sub>4<\/sub>\n                    and MTX for hyperthermia"],"prefix":"10.1049","volume":"14","author":[{"given":"Nada","family":"Saleh","sequence":"first","affiliation":[{"name":"Polymer Research Lab Department of Materials Engineering School of Chemical and Materials Engineering (SCME) National University of Sciences and Technology (NUST) NUST H\u201012 Campus Islamabad 44000 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Quaid\u2010i\u2010Azam University Islamabad 45320 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Imran Asad","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Quaid\u2010i\u2010Azam University Islamabad 45320 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqra","family":"Chaudhery","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Quaid\u2010i\u2010Azam University Islamabad 45320 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasir","family":"Mahmoud Ahmad","sequence":"additional","affiliation":[{"name":"Polymer Research Lab Department of Materials Engineering School of Chemical and Materials Engineering (SCME) National University of Sciences and Technology (NUST) NUST H\u201012 Campus Islamabad 44000 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"265","published-online":{"date-parts":[[2019,12,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19072006"},{"issue":"11","key":"e_1_2_6_3_1","first-page":"1249","article-title":"Magnetic nanoparticles in cancer theranostics","volume":"5","author":"Gobbo O.L","year":"2015","journal-title":"Natl. 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