{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:02:23Z","timestamp":1783422143820,"version":"3.54.6"},"reference-count":37,"publisher":"Institution of Engineering and Technology (IET)","issue":"5","license":[{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ietresearch.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IET Nanobiotechnology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>\n                    Fluconazole\u2010resistant\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    is a big scary reality. The authors assessed the antifungal effects of magnetic iron\u2010oxide nanoparticles on fluconazole\u2010resistant colonising isolate of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    and determined the expression of\n                    <jats:italic>ERG11<\/jats:italic>\n                    gene, protein sequence similarity and ergosterol content.\n                    <jats:italic>C. albicans<\/jats:italic>\n                    isolates were characterised and fluconazole resistance is recognised using World Health Organization's WHONET software. Susceptibility testing of magnetic iron\u2010oxide nanoparticles against fluconazole\u2010resistant colonising isolate of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    was performed according to Clinical and Laboratory Standards Institute guidelines. The expression patterns of\n                    <jats:italic>ERG11<\/jats:italic>\n                    and protein sequence similarity were investigated. Ergosterol quantification has been used to gauge the antifungal activity of magnetic iron\u2010oxide nanoparticles. The findings indicated that 93% of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    isolates were resistant to fluconazole. Magnetic iron\u2010oxide nanoparticles were presented activity against fluconazole\u2010resistant colonising isolate of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    with minimum inhibitory concentration at 250\u2013500 \u00b5g\/ml. The expression level of\n                    <jats:italic>ERG11<\/jats:italic>\n                    gene was downregulated in fluconazole\u2010resistant colonising isolate of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    . The results revealed no differences in fluconazole\u2010resistant colonising isolate of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    by comparison with ERG11 reference sequences. Moreover, significant reduction was noted in ergosterol content. The findings shed a novel light on the application of magnetic iron\u2010oxide nanoparticles in fighting against resistant\n                    <jats:italic>C. albicans<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1049\/iet-nbt.2019.0354","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T14:14:52Z","timestamp":1594044892000},"page":"375-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Inhibitory effect of magnetic iron\u2010oxide nanoparticles on the pattern of expression of lanosterol 14\n                    <i>\u03b1<\/i>\n                    \u2010demethylase (\n                    <i>ERG11<\/i>\n                    ) in fluconazole\u2010resistant colonising isolate of\n                    <i>Candida albicans<\/i>"],"prefix":"10.1049","volume":"14","author":[{"given":"Mohammad","family":"Zare\u2010Khafri","sequence":"first","affiliation":[{"name":"Department of Microbiology Yasooj Branch Islamic Azad University Yasooj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7074-0464","authenticated-orcid":false,"given":"Fahimeh","family":"Alizadeh","sequence":"additional","affiliation":[{"name":"Department of Microbiology Yasooj Branch Islamic Azad University Yasooj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadegh","family":"Nouripour\u2010Sisakht","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Centre, Yasuj University of Medical Sciences Yasuj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Khodavandi","sequence":"additional","affiliation":[{"name":"Department of Biology Gachsaran Branch Islamic Azad University Gachsaran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Gerami","sequence":"additional","affiliation":[{"name":"Education Research Centre, Yasuj University Yasuj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"265","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx444"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.075"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.810440"},{"issue":"7","key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"a019752","DOI":"10.1101\/cshperspect.a019752","article-title":"Mechanisms of antifungal drug resistance","volume":"5","author":"Cowen L.E.","year":"2014","journal-title":"Cold Spring Harb. 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