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The generation of metallic nanocomposites using biological compounds is emerging as a new promising strategy for this purpose. In this study, four metallic nanoparticles (NPs) with propolis extract (Ext) and one without propolis including ZnO\/Ext, ZnO\/Ag\/Ext, ZnO\/CuO\/Ext, ZnO\/Ag\/CuO\/Ext and ZnO\/W were prepared by microwave method and assessed for their wound healing activity on excision experimental model of wounds in rats. The developed nanocomposites have been characterised by physico\u2010chemical methods such as X\u2010ray diffraction, scanning electron microscopy, diffuse reflectance UV\u2013vis spectroscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis and Brunauer\u2013Emmett\u2013Teller analyses. The wounded animals treated with the NPs\/Ext in five groups for 18\u00a0days. Every 6\u00a0days, for measuring wound closure rate, three samples of each group were examined for histopathological analysis. The prepared tissue sections were investigated by haematoxylin and Eosin stainings for the formation of epidermis, dermis and muscular and Masson's trichrome staining for the formation of collagen fibres. These findings toughly support the probability of using this new ZnO\/Ag\/Ext materials dressing for a wound care performance with significant effect compared to other NPs.<\/jats:p>","DOI":"10.1049\/iet-nbt.2020.0024","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T22:15:38Z","timestamp":1587075338000},"page":"548-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Biologically\u2010synthesised ZnO\/CuO\/Ag nanocomposite using propolis extract and coated on the gauze for wound healing applications"],"prefix":"10.1049","volume":"14","author":[{"given":"Mahdi","family":"Bayrami","sequence":"first","affiliation":[{"name":"Department of Biology Faculty of Science University of Mohaghegh Ardabili Ardabil Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolfazl","family":"Bayrami","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Science University of Mohaghegh Ardabili Ardabil Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziz","family":"Habibi\u2010Yangjeh","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science University of Mohaghegh Ardabili Ardabil Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Saleh","family":"Shafeeyan","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Faculty of Engineering Golestan University Aliabad Katoul Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solmaz","family":"Feizpoor","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science University of Mohaghegh Ardabili Ardabil Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3505-890X","authenticated-orcid":false,"given":"Farid Mohammadi","family":"Arvanagh","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Science University of Mohaghegh Ardabili Ardabil Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Nourani","sequence":"additional","affiliation":[{"name":"Nanobiotechnology Research Center Baqiyatallah University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramezan Ali","family":"Taheri","sequence":"additional","affiliation":[{"name":"Nanobiotechnology Research Center Baqiyatallah University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"265","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"VishwakarmaK.: \u2018Green synthesis of ZnO nanoparticles using abrus precatorius seeds extract and their characterization\u2019 PhD thesis National Institute of Technology Rourkela 2013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2006.10.045"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.03.022"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.05.005"},{"key":"e_1_2_6_6_1","first-page":"37","volume-title":"Application of laser scanning microscopy for the characterization of wound healing","author":"Alborova A.","year":"2007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1049\/iet-nbt.2019.0188"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1049\/iet-nbt.2019.0108"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2019.03.010"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.09.051"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200600171"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2007.06.006"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2019.104613"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(02)00185-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02540666"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(99)00189-0"},{"key":"e_1_2_6_17_1","first-page":"323","article-title":"Chemical composition of Egyptian and commercial propolis and its effects on liver function and lipid profiles in albino rats","volume":"8","author":"Abdelaal A.","year":"2013","journal-title":"J. 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