{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:08:03Z","timestamp":1777370883121,"version":"3.51.4"},"reference-count":42,"publisher":"Institution of Engineering and Technology (IET)","issue":"4","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IET Systems Biology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>The natural products containing aristolochic acid (AA) have been widely used for acne, gastritis and so on. Recently, it is becoming accepted that AA may be responsible for acute and chronic renal failures as the side effects of Chinese herbs. However, it is unclear what happens in the cells after the AA treatment. In this study, the authors built a gene regulatory network as well as a microRNA\u2013gene regulatory network to investigate the molecular dynamics induced by AA from a systematic perspective. With the regulatory networks, they detected some important pathways and biological processes that were affected by AA treatment, which can help explain the nephrotoxicity and carcinogenicity of AA. They found some important regulators and genes responding to AA treatment, and these genes have been reported to be related to the kidney functions, indicating their important roles in the toxicity of AA.<\/jats:p>","DOI":"10.1049\/iet-syb.2014.0057","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T07:43:02Z","timestamp":1430984582000},"page":"141-146","source":"Crossref","is-referenced-by-count":3,"title":["Understanding the aristolochic acid toxicities in rat kidneys with regulatory networks"],"prefix":"10.1049","volume":"9","author":[{"given":"Yin\u2010Ying","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Systems Biology Shanghai University Shanghai 200444 People's Republic of China"},{"name":"School of Communication and Information Engineering Shanghai University Shanghai 200444 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiguang","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Cancer Stem Cell Cancer Center Dalian Medical University 9\u00a0Lvshun Road South, Dalian Liaoning 116044 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Genetic and Molecular Toxicology National Center for Toxicological Research US Food and Drug Administration Jefferson AR 72079 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing\u2010Ming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Computer Science School of Electronics and Information Engineering Tongji University Shanghai 201804 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"265","published-online":{"date-parts":[[2015,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90964-4"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.129"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/17.4.265"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/15563650600671712"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2009.197"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx200103b"},{"key":"e_1_2_6_8_2","first-page":"1","article-title":"Identifying cancer\u2010related microRNAs based on gene expression data","author":"Zhao X.M.","year":"2014","journal-title":"Bioinformatics"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05939"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201005\u20100137"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2014.06.007"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0219720009004138"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u201013\u2010126"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl\u20102011\u2010000658"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013021"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.1.207"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb\u20102010\u201011\u201010\u2010r106"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2011.08.009"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1938"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb\u20102010\u201011\u20108\u2010r90"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr965"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/geu027"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.56"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2012.02.003"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024541"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.10.024"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010013\u20100557\u20100"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn923"},{"issue":"1","key":"e_1_2_6_29_2","first-page":"141","article-title":"Aristolochic acid suppresses DNA repair and triggers oxidative DNA damage in human kidney proximal tubular cells","volume":"24","author":"Chen Y.Y.","year":"2010","journal-title":"Oncol. Rep."},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u20107\u2010S2\u2010S20"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90435.2008"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2011.01.021"},{"issue":"1","key":"e_1_2_6_33_2","first-page":"S81","article-title":"Tumor\u2010induced dysfunction in interleukin\u20102 production and interleukin\u20102 receptor signaling: a mechanism of immune escape","volume":"6","author":"Rayman P.","year":"2000","journal-title":"Cancer J. Sci. Am."},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90420.2008"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(97)01103-7"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl842"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035661"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.044396"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/phy2.136"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/1752\u20100509\u20104\u201051"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2008.06.006"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.180729"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.11.163"}],"container-title":["IET Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1049\/iet-syb.2014.0057","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1049\/iet-syb.2014.0057","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ietresearch.onlinelibrary.wiley.com\/doi\/pdf\/10.1049\/iet-syb.2014.0057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:08:48Z","timestamp":1761689328000},"score":1,"resource":{"primary":{"URL":"https:\/\/ietresearch.onlinelibrary.wiley.com\/doi\/10.1049\/iet-syb.2014.0057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1049\/iet-syb.2014.0057"],"URL":"https:\/\/doi.org\/10.1049\/iet-syb.2014.0057","archive":["Portico"],"relation":{},"ISSN":["1751-8849","1751-8857"],"issn-type":[{"value":"1751-8849","type":"print"},{"value":"1751-8857","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8]]}}}