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The uncertain parameters of the model are updated by appropriate design of adaptation laws using the Lyapunov method. The closed\u2010loop response of the plasma glucose concentration as well as external insulin infusion rate is analysed for a wide range of variation of the model parameters through extensive simulation studies. The result indicates that the proposed adaptive control scheme avoids severe hypoglycaemia and gives satisfactory performance under parametric uncertainty highlighting its ability to address the issue of inter\u2010patient variability.<\/jats:p>","DOI":"10.1049\/iet-syb.2017.0093","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T22:10:50Z","timestamp":1525126250000},"page":"219-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Blood glucose regulation in type 1 diabetic patients: an adaptive parametric compensation control\u2010based approach"],"prefix":"10.1049","volume":"12","author":[{"given":"Anirudh","family":"Nath","sequence":"first","affiliation":[{"name":"Electrical Engineering Department National Institute of Technology Silchar 788010 Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipankar","family":"Deb","sequence":"additional","affiliation":[{"name":"Electrical Engineering Department Institute of Infrastructure Technology Research and Management Ahmedabad 380026 Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeeb","family":"Dey","sequence":"additional","affiliation":[{"name":"Electrical Engineering Department National Institute of Technology Silchar 788010 Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sipon","family":"Das","sequence":"additional","affiliation":[{"name":"Electrical Engineering Department National Institute of Technology Silchar 788010 Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"265","published-online":{"date-parts":[[2018,10]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"1985 Massachusetts Institute of Technology J.T. 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