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It has been a matter of concern for the scientific community to develop an antiretroviral therapy, which will prompt a rapid decline in viral abundance. With this motivation, this study proposes the design of a robust super twisting sliding mode controller based on output information for an uncertain HIV infection model. The control objective is to decrease the concentration of infected CD4+ T cells to a specified level by drug administration using only the output information of the uncertain HIV infection model which is total CD4+ T cell concentration. The robust output\u2010feedback controller has been developed in combination with a robust exact differentiator, functioning as an observer. The reported analysis demonstrates that the approach proposed here is capable of ensuring robust performance under several operating conditions, measurement and modelling error, parametric uncertainties and external disturbances and the simulation results prove the proficiency of the controller proposed.<\/jats:p>","DOI":"10.1049\/iet-syb.2018.5063","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:35:28Z","timestamp":1547512528000},"page":"120-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Robust control of HIV infection by antiretroviral therapy: a super\u2010twisting sliding mode control approach"],"prefix":"10.1049","volume":"13","author":[{"given":"Manas Kumar","family":"Bera","sequence":"first","affiliation":[{"name":"Department of Electronics and Instrumentation Engineering National Institute of Technology Silchar Silchar 788010 Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pintu","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering National Institute of Technology Silchar Silchar 788010 Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj Kumar","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering National Institute of Technology Silchar Silchar 788010 Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"265","published-online":{"date-parts":[[2019,6]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"\u2018World Health Organization\u2019. 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