{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:28:27Z","timestamp":1790116107086,"version":"4.0.1"},"reference-count":46,"publisher":"Institution of Engineering and Technology (IET)","issue":"5","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["ietresearch.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IET Nanobiotechnology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study examines the effect of nanoparticles with zinc oxides (ZnONPs) on diabetic nephropathy, which is the primary cause of mortality for diabetic patients with end\u2010stage renal disease. Diabetes in adult male rats was induced via intraperitoneal injection of streptozotocin. ZnONPs were intraperitoneally administered to diabetic rats daily for 7 weeks. Diabetes was associated with increases in blood glucose level, 24\u2010h urinary albumin excretion rate, glomerular basement membrane thickness, renal oxidative stress markers, and renal mRNA or protein expression of transforming growth factor\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1, fibronectin, collagen\u2010IV, tumour necrosis factor\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    and vascular endothelial growth factor\u2010A. Moreover, the expression of nephrin and podocin, and the mRNA expression of matrix metalloproteinase\u20109 were decreased in the diabetic group. These changes were not detected in the control group and were significantly prevented by ZnONP treatment. These results provide evidence that ZnONPs ameliorate the renal damage induced in a diabetic rat model of nephropathy through improving renal functionality; inhibiting renal fibrosis, oxidative stress, inflammation and abnormal angiogenesis; and delaying the development of podocyte injury. The present findings may help design the clinical application of ZnONPs for protection against the development of diabetic nephropathy.\n                  <\/jats:p>","DOI":"10.1049\/nbt2.12026","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T02:50:40Z","timestamp":1615431040000},"page":"473-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Alleviation of diabetic nephropathy by zinc oxide nanoparticles in streptozotocin\u2010induced type 1 diabetes in rats"],"prefix":"10.1049","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1210-124X","authenticated-orcid":false,"given":"Ghada","family":"Alomari","sequence":"first","affiliation":[{"name":"Department of Bioscience, Faculty of Science Universiti Teknologi Malaysia  Johor Bahru Johor Malaysia"},{"name":"Department of Biological Sciences Yarmouk University  Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahaa","family":"Al\u2010Trad","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Yarmouk University  Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salehhuddin","family":"Hamdan","sequence":"additional","affiliation":[{"name":"Department of Bioscience, Faculty of Science Universiti Teknologi Malaysia  Johor Bahru Johor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa A. A.","family":"Aljabali","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology Faculty of Pharmacy Yarmouk University  Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0248-4777","authenticated-orcid":false,"given":"Mazhar Salim","family":"Al Zoubi","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences Faculty of Medicine Yarmouk University  Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3575-2443","authenticated-orcid":false,"given":"Khalid","family":"Al\u2010Batanyeh","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Yarmouk University  Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janti","family":"Qar","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Yarmouk University  Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Eaton","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences College of Science and Mathematics Rowan University  Glassboro New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almuthanna K.","family":"Alkaraki","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Yarmouk University  Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walhan","family":"Alshaer","sequence":"additional","affiliation":[{"name":"University of Jordan Cell Therapy Center  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saja","family":"Haifawi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Yarmouk University  Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khairunadwa","family":"Jemon","sequence":"additional","affiliation":[{"name":"Department of Bioscience, Faculty of Science Universiti Teknologi Malaysia  Johor Bahru Johor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh Kumar","family":"Chellappan","sequence":"additional","affiliation":[{"name":"Department of Life Sciences School of Pharmacy International Medical University  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Dua","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy The University of Newcastle  Callaghan Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murtaza M.","family":"Tambuwala","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Science Ulster University  Coleraine UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"265","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.1.164"},{"issue":"5","key":"e_1_2_7_3_1","first-page":"47","article-title":"Pathophysiological changes in diabetic nephropathy","volume":"66","author":"Mojaddidi M.A.","year":"2013","journal-title":"Arch. 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