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To enhance the storage capacity of hair follicles and alleviate the inherent characteristics of dutasteride, 5\u2010alpha\u00a0reductase\u00a0inhibitor, a prolonged\u2010release nanocarrier was synthesised, and its influence on rat abdomen's skin was investigated. Results showed the lower ratio of S\/Co (higher ethanol concentration) increased the hydrodynamic nanocarriers' particle size due to thermodynamic disturbance and Ostwald ripening. In contrast, an increase in surfactant through a decrease in interfacial tension resulted in smaller nanocarriers of 32.4\u00a0nm. Moreover, an increase in viscosity had an inverse correlation with the nanoemulsions' particle size. Nanocarriers containing ethanol showed less entrapment efficacy, perhaps due to the rapid dissolution of dutasteride into ethanol during nanoemulsification, while, based on Stokes' equation, the addition of ethanol resulted in smaller particle size and stability of the system. Skin permeation analysis using Franz diffusion cells showed nanocarriers could pass through the skin and release dutasteride for 6\u00a0days. In conclusion, the optimum concentration of ingredients is decisive in guaranteeing the ideal particle size, stability, and skin permeation of nanocarriers. The Present dutasteride nanocarrier would promise a prolonged and sustained\u2010release drug delivery system for Alopecia therapy.<\/jats:p>","DOI":"10.1049\/nbt2.12101","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T07:48:36Z","timestamp":1667202516000},"page":"13-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dutasteride nanoemulsion preparation to inhibit 5\u2010alpha\u2010hair follicle reductase enzymes in the hair follicle; an ex vivo study"],"prefix":"10.1049","volume":"17","author":[{"given":"Mehri","family":"Memar Bashi Aval","sequence":"first","affiliation":[{"name":"Department of Medical Nanotechnology Faculty of Advanced Sciences and Technology Pharmaceutical Sciences Branch Islamic Azad University, (IAUPS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Hoveizi","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Science Shahid Chamran University of Ahvaz  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Mombeiny","sequence":"additional","affiliation":[{"name":"Department of Medical Nanotechnology Faculty of Advanced Technologies in Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Kazemi","sequence":"additional","affiliation":[{"name":"Department of Medical Nanotechnology Faculty of Advanced Technologies in Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeedeh","family":"Saeedi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry School of Pharmacy Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Pharmaceutical Sciences College of Pharmacy University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8531-7650","authenticated-orcid":false,"given":"Shima","family":"Tavakol","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"265","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.09.025"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmec.2008.04.006"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/b505793k"},{"issue":"4","key":"e_1_2_10_5_1","first-page":"1125","article-title":"Preparation, characterization and stability study of dutasteride loaded nanoemulsion for treatment of benign prostatic hypertrophy","volume":"13","author":"Ali M.S.","year":"2014","journal-title":"Iran. 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