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Here, synthesised GNPs were coated with polyethylene glycol. Then these particles were conjugated with paclitaxel under different conditions and the physical and structural characteristics, as well as the factors affecting the loading of paclitaxel on nanoparticles, were evaluated by ultraviolet spectrophotometer, fourier transform infrared\u00a0spectroscopy, transmission electron microscopy, dynamic light scattering and zeta potential apparatus. It was found that pegylated GNPs have a limited loading capacity at the time of 24\u00a0h of incubation and the Paclitaxel loading was observed to be pH dependent. The use of these particles in the treatment of breast cancer (MCF7) was also investigated using the MTT test. It was determined that the survival percentage of MCF7 cells in the presence of paclitaxel\u2010bound nanoparticles decreases to about 55% at the maximum measured concentration (690\u00a0\u03bcM).<\/jats:p>","DOI":"10.1049\/nbt2.12121","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T21:44:21Z","timestamp":1677534261000},"page":"234-245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of the parameters affecting the loading of anticancer drug Paclitaxel on coated gold nanoparticles for breast cancer treatment"],"prefix":"10.1049","volume":"17","author":[{"given":"Afrooz","family":"kharazmi","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Applied Biophotonics Research Center Tehran Science and Research Branch Islamic Azad University  Tehran 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