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However, it induces damage to the surrounding healthy tissue and possibly further away areas. Therefore, it is necessary to give a lower dose to the patient with targeted therapy. In this study, the radio\u2010sensitising effect of gold\u2010coated iron oxide nanoparticles on electron beam radiotherapy of a melanoma tumour with magnetic targeting in a mouse model was investigated. Gold\u2010coated iron oxide nanoparticles were prepared in a steady procedure. The melanoma tumour model was induced in mice. Animals were divided into five groups: (1) normal; (2) melanoma; (3) gold\u2010coated iron oxide nanoparticles alone; (4) electron beam radiotherapy; (5) electron beam radiotherapy plus gold\u2010coated iron oxide nanoparticles. The magnet was placed on the tumour site for 2\u00a0h. The tumours were then exposed to 6\u00a0MeV electron beam radiotherapy for a dose of 8\u00a0Gy. Inductively coupled plasma optical emission spectrometry test, hematoxylin and eosin\u00a0staining, and enzyme\u2010linked immunosorbent assay\u00a0blood test were also performed. Gold\u2010coated iron oxide nanoparticles with magnetic targeting before electron beam radiotherapy reduced the growth of the tumour compared to the control group. Blood tests did not show any significant toxicity. Deposition of nanoparticles was more in the tumour and spleen tissue and to a lesser extent in the liver, kidney, and lung tissues. The synergistic effect of nanoparticles administered by the intraperitoneal route and then concentrated into the tumour area by application of an external permanent magnet, before delivery of the electron beam radiotherapy improved the overall cancer treatment outcome and prevented metal distribution side effects.<\/jats:p>","DOI":"10.1049\/nbt2.12129","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T08:00:48Z","timestamp":1682064048000},"page":"212-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Radiosensitising effect of iron oxide\u2010gold nanocomplex for electron beam therapy of melanoma in vivo by magnetic targeting"],"prefix":"10.1049","volume":"17","author":[{"given":"Mahshad","family":"Mohamadkazem","sequence":"first","affiliation":[{"name":"Radiation Biology Research Center Iran University of Medical Science (IUMS)  Tehran Iran"},{"name":"Radiation Science Department Iran University of Medical Science (IUMS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8576-4613","authenticated-orcid":false,"given":"Ali","family":"Neshastehriz","sequence":"additional","affiliation":[{"name":"Radiation Biology Research Center Iran University of Medical Science (IUMS)  Tehran Iran"},{"name":"Radiation Science Department Iran University of Medical Science (IUMS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6447-9872","authenticated-orcid":false,"given":"Seyed Mohammad","family":"Amini","sequence":"additional","affiliation":[{"name":"Radiation Biology Research Center Iran University of Medical Science (IUMS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Moshiri","sequence":"additional","affiliation":[{"name":"Radiation Biology Research Center Iran University of Medical Science (IUMS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atousa","family":"Janzadeh","sequence":"additional","affiliation":[{"name":"Radiation Biology Research Center Iran University of Medical Science (IUMS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"265","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31559-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/ITT.S134842"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-020-03663-w"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5489"},{"key":"e_1_2_10_6_1","volume-title":"Radiobiology for the Radiologist","author":"Hall E.J.","year":"2006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12855"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-021-03399-7"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR14578.1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1088\/2043-6254\/abc758"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10934-021-01137-6"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2011.01.014"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.5101\/nbe.v4i1.p6-11"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553002.2017.1231944"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553002.2017.1276309"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42826-019-0015-z"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1142\/S1793292022500370"},{"issue":"4","key":"e_1_2_10_18_1","first-page":"204","article-title":"A prospective analysis of factors that influence weight loss in patients undergoing radiotherapy","volume":"33","author":"Cacicedo J.","year":"2014","journal-title":"Chin. 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