{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:56:52Z","timestamp":1790092612382,"version":"4.0.1"},"reference-count":17,"publisher":"Institution of Engineering and Technology (IET)","issue":"4","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["ietresearch.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IET Nanobiotechnology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Atherosclerosis is a progressive inflammatory disease characterised by excessive lipid accumulation and inflammatory cell infiltration and is the basis of most cardiovascular diseases and peripheral arterial diseases. Therefore, an effectively targeted delivery system is urgently needed to deliver ferroptosis\u2010specific inhibitors to the site of arterial plaque and the inflammatory microenvironment. Inspired by the fact that neutrophils can be recruited to arterial plaques under the action of adhesion molecules and chemokines, the authors developed a neutrophil membrane hybrid liposome nano\u2010mimetic system (Ptdser\u2010NM\u2010Lipo\/Fer\u20101) that delivers Ferrostatin\u20101 (Fer\u20101) to the atherosclerotic plaque effectively, which is composed of Fer\u20101\u2010loaded Ptdser\u2010modified liposomes core and neutrophils shell. Fer\u20101 was released at the AS plaque site to remove reactive oxygen species (ROS) and improve the inflammatory microenvironment. In vitro ROS clearance experiments have shown that 50\u00a0\u03bcmol\/ml Fer\u20101 can significantly remove ROS produced by H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced MOVAS cells and Ptdser\u2010NM\u2010Lipo\/Fer\u20101 revealed a 3\u2010fold increase in the inhibition rate of ROS than free Fer\u20101 in induced\u2010RAW264.7, demonstrating its superior ROS\u2010cleaning effect. Based on the interaction of adhesion molecules, such as vascular cell adhesion molecule 1, ICAM\u20101, P\u2010selectin, E\u2010selectin, and chemokines released in the inflamed site, the aorta in NM\u2010Lipo\u2010treated mice displayed 1.3\u2010fold greater radiant efficiency than platelet membrane\u2010Lipo\u2010treated mice. Meanwhile, due to the modification of the Ptdser, the aorta in Ptdser\u2010NM\u2010Lipo\/Fer\u20101\u2010treated mice exhibited the highest fluorescence intensity, demonstrating its excellent targeting ability for atherosclerosis. Therefore, we present a specific formulation for the treatment of atherosclerosis with the potential for novel therapeutic uses.\n                  <\/jats:p>","DOI":"10.1049\/nbt2.12137","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T04:06:38Z","timestamp":1684123598000},"page":"387-395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Neutrophil membrane biomimetic delivery system (Ptdser\u2010NM\u2010Lipo\/Fer\u20101) designed for targeting atherosclerosis therapy"],"prefix":"10.1049","volume":"17","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology Zhongda Hospital School of Medicine Southeast University  Nanjing China"},{"name":"Department of Cardiology Affiliated Hospital of Yangzhou University Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0200-1627","authenticated-orcid":false,"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics State Key Laboratory of Nature Medicines China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sichuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Affiliated Hospital of Yangzhou University Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naifeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zhongda Hospital School of Medicine Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"265","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010021\u201000668\u20104"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.01.007"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010021\u201000584\u20101"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.09.008"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.63"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010019\u20100720\u2010y"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.809516"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010018\u20100031\u20106"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.07.019"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2017.54"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.09.027"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.04.068"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci90520"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010018\u20100113\u20103"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2018.08.002"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtchem.2022.101062"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3770"}],"container-title":["IET Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ietresearch.onlinelibrary.wiley.com\/doi\/pdf\/10.1049\/nbt2.12137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:13:28Z","timestamp":1761693208000},"score":1,"resource":{"primary":{"URL":"https:\/\/ietresearch.onlinelibrary.wiley.com\/doi\/10.1049\/nbt2.12137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,15]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1049\/nbt2.12137"],"URL":"https:\/\/doi.org\/10.1049\/nbt2.12137","archive":["Portico"],"relation":{},"ISSN":["1751-8741"],"issn-type":[{"value":"1751-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5,15]]},"assertion":[{"value":"2023-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}