{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:58:10Z","timestamp":1790834290008,"version":"4.1.0"},"reference-count":51,"publisher":"Institution of Engineering and Technology (IET)","issue":"5","license":[{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ietresearch.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IET Nanobiotechnology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Efficient drug delivery systems (DDSs) can potentially replace with conventional modalities in cancer therapy, like liver cancer. In this study, a novel folic acid (FA)\u2010functionalised and alginate (Alg)\u2010modified poly lactic\u2010co\u2010glycolic acid (PLGA) nanocomposite was developed for delivery of doxorubicin (Dox) to HepG2 and Huh7 liver cancer cells. After synthesising the nanocarrier, several analytical devices, including FT\u2010IR, DLS, TGA, and TEM, were employed for its characterisation. Nano\u2010metric size (55 and 85\u00a0nm in diameter), close to neutral surface charge, semi\u2010spherical morphology, and successful synthesis were approved. Dox entrapment efficiency was determined near 1%, and sustained and pH\u2010sensitive drug release behaviours of nanocarrier were ascertained for DDS. Afterwards, the cell viability test was carried out to study the HepG2 and Huh7 cells suppression capability of FA\u2010PLGA\u2010Dox\u2010Alg. About 12% and 10% cell viabilities were observed in HepG2 and Huh7 cancer cells after 24\u00a0h treatment with 400\u00a0nM concentration of FA\u2010PLGA\u2010Dox\u2010Alg nanocarrier respectively. The IC\n                    <jats:sub>50<\/jats:sub>\n                    value was observed for 100\u00a0nM after 24\u00a0h of treatment in cancer cells. These data have indicated that fabricated nanocarrier could be promising DDS against liver cancer and replace with conventional approaches in cancer treatment, like chemotherapy.\n                  <\/jats:p>","DOI":"10.1049\/nbt2.12143","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T04:56:27Z","timestamp":1686632187000},"page":"450-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Poly lactic\u2010co\u2010glycolic acid\u2010alginate nanocarrier for efficient drug delivery to liver cancer cells"],"prefix":"10.1049","volume":"17","author":[{"given":"Mahsa","family":"Hoseinzadeh","sequence":"first","affiliation":[{"name":"Department of Biology Jahrom Branch Islamic Azad University  Jahrom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5066-9632","authenticated-orcid":false,"given":"Mohammad 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