{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:34:58Z","timestamp":1793212498663,"version":"4.5.0"},"reference-count":57,"publisher":"Institution of Engineering and Technology (IET)","issue":"6","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["1U2RTW010679"],"award-info":[{"award-number":["1U2RTW010679"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U24HG006941"],"award-info":[{"award-number":["U24HG006941"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ietresearch.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IET Systems Biology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Burkitt lymphoma (BL) is one of the most aggressive forms of non\u2010Hodgkin's lymphomas that affect children and young adults. The expression of genes and other molecular markers during carcinogenesis can be the basis for diagnosis, prognosis and the design of new and effective drugs for the management of cancers. The aim of this study was to identify genes that can serve as prognostic and therapeutic targets for BL. We analysed RNA\u2010seq data of BL transcriptome sequencing projects in Africa using standard RNA\u2010seq analyses pipeline. We performed pathway enrichment analyses, protein\u2013protein interaction networks, gene co\u2010expression and survival analyses. Gene and pathway enrichment analyses showed that the differentially expressed genes are involved in tube development, signalling receptor binding, viral protein interaction, cell migration, external stimuli response, serine hydrolase activity and PI3K\u2010Akt signalling pathway. Protein\u2013protein interaction network analyses revealed the genes to be highly interconnected, whereas module analyses revealed 25 genes to possess the highest interaction score. Overall survival analyses delineated six genes (ADAMTSL4, SEMA5B, ADAMTS15, THBS2, SPON1 and THBS1) that can serve as biomarkers for prognosis for BL management.<\/jats:p>","DOI":"10.1049\/syb2.12054","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T05:25:44Z","timestamp":1668057944000},"page":"220-229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Genes associated with diagnosis and prognosis of Burkitt lymphoma"],"prefix":"10.1049","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0152-9999","authenticated-orcid":false,"given":"Albert","family":"Doughan","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology College of Science Faculty of Biosciences Kwame Nkrumah University of Science and Technology (KNUST)  Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2092-6452","authenticated-orcid":false,"given":"Samson Pandam","family":"Salifu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology College of Science Faculty of Biosciences Kwame Nkrumah University of Science and Technology (KNUST)  Kumasi Ghana"},{"name":"Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR)  Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"265","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2011.08877.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/ahmt.s94170"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(08)70175\u2010x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201009\u2010871418"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001880"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541\u20107786.mcr\u201016\u20100305"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005158"},{"issue":"6","key":"e_1_2_10_9_1","first-page":"1389","article-title":"Wnt signaling pathway protein LEF1 in cancer, as a biomarker for prognosis and a target for treatment","volume":"7","author":"Santiago L.","year":"2017","journal-title":"Am. 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