{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:13:31Z","timestamp":1780989211684,"version":"3.54.1"},"reference-count":41,"publisher":"Institution of Engineering and Technology (IET)","issue":"6","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ietresearch.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IET Systems Biology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Abdominal aortic aneurysm (AAA) is a severe vascular condition, marked by the progressive dilation of the abdominal aorta, leading to rupture if untreated. The objective of this study was to identify key biomarkers and decipher the immune mechanisms underlying AAA utilising multi\u2010omics data analysis and machine learning techniques. Single\u2010cell RNA sequencing disclosed a heightened presence of macrophages and CD8\u2010positive alpha\u2010beta T cells in AAA, highlighting their critical role in disease pathogenesis. Analysis of cell\u2013cell communication highlighted augmented interactions between macrophages and dendritic cells derived from monocytes. Enrichment analysis of differential expression gene indicated substantial involvement of immune and metabolic pathways in AAA pathogenesis. Machine learning techniques identified CCR7 and CBX6 as key candidate biomarkers. In AAA, CCR7 expression is upregulated, whereas CBX6 expression is downregulated, both showing significant correlations with immune cell infiltration. These findings provide valuable insights into the molecular mechanisms underlying AAA and suggest potential biomarkers for diagnosis and therapeutic intervention.<\/jats:p>","DOI":"10.1049\/syb2.12106","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T13:05:21Z","timestamp":1732712721000},"page":"250-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of CCR7 and CBX6 as key biomarkers in abdominal aortic aneurysm: Insights from multi\u2010omics data and machine learning analysis"],"prefix":"10.1049","volume":"18","author":[{"given":"Xi","family":"Yong","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery Affiliated Hospital of North Sichuan Medical College  Nanchong China"},{"name":"The First Affiliated Hospital Jinan University  Guangzhou China"},{"name":"Hepatobiliary Pancreatic and Intestinal Research Institute of North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuerui","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Endocrine Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengyao","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Affiliated Hospital of North Sichuan Medical College  Nanchong China"},{"name":"Department of Clinical Medicine North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanpiao","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuihan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yani","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"You","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohe","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghua","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Affiliated Hospital of North Sichuan Medical College  Nanchong China"},{"name":"Department of Clinical Medicine North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7058-2787","authenticated-orcid":false,"given":"Qin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingdong","family":"Li","sequence":"additional","affiliation":[{"name":"Hepatobiliary Pancreatic and Intestinal Research Institute of North Sichuan Medical College  Nanchong China"},{"name":"Department of Clinical Medicine North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"265","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.671859"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.05.090"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.10.097"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199909000\u201000002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x02vm444xx"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/hco.0b013e328330c2d3"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570161115666170413145705"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(05)66459\u20108"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa214"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915\u2010024\u201001950\u2010w"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eswa.2024.124702"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fmre.2024.01.020"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0118"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.120.315607"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201839"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1291352"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753944717750338"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.12.017"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemolab.2022.104697"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073\u2010023\u201001249\u20105"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab638"},{"key":"e_1_2_10_23_1","unstructured":"Alghushairy O. et\u00a0al.:Machine Learning\u2010Based Model for Accurate Identification of Druggable Proteins Using Light Extreme Gradient Boosting pp.1\u201312(2023)"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009234\u20106"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac848"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3337"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemolab.2021.104484"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.52"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14122438"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13697"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102222\u2010z"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eswa.2022.116729"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2024.04.004"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872\u2010018\u20100766\u20108"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2023.10.052"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202400009"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.10.012"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.12.043"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41597\u2010024\u201003104\u20107"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9916881"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578\u2010023\u201000991\u2010y"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2023.102044"}],"container-title":["IET Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ietresearch.onlinelibrary.wiley.com\/doi\/pdf\/10.1049\/syb2.12106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T19:52:42Z","timestamp":1761681162000},"score":1,"resource":{"primary":{"URL":"https:\/\/ietresearch.onlinelibrary.wiley.com\/doi\/10.1049\/syb2.12106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1049\/syb2.12106"],"URL":"https:\/\/doi.org\/10.1049\/syb2.12106","archive":["Portico"],"relation":{},"ISSN":["1751-8849","1751-8857"],"issn-type":[{"value":"1751-8849","type":"print"},{"value":"1751-8857","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,27]]},"assertion":[{"value":"2024-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}