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We conducted a comprehensive study, integrating mRNA data, immunohistochemistry, CRISPR\u2010modified cell line analysis and single\u2010cell RNA sequencing to assess SAE1's role in PAAD. We also used ChIP\u2010Seq to explore SAE1's transcriptional regulation and analysed clinical data, drug sensitivity and molecular docking models. SAE1 mRNA was significantly overexpressed in PAAD, with a substantial impact on cell proliferation and migration. Functional analyses linked SAE1 to cell cycle and DNA replication pathways, suggesting a role in PAAD development. 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