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However, comprehensive screening of mitochondrial\u2010related genes (MRGs) and their mechanistic roles in AP progression remains limited. We integrated transcriptomic data with MRGs from the MitoCarta database. A total of 34 differentially expressed MRGs were identified, enabling classification of AP samples into three molecular subtypes with distinct immune cell infiltration patterns and clinical severity. Three hub genes were consistently identified by three machine learning algorithms: LASSO, SVM\u2010RFE, and RF. qRT\u2010PCR validation in cellular models confirmed consistent expression trends. Multi\u2010level functional annotation was conducted through GSVA, CIBERSORT, transcription factor prediction, subcellular localisation and single\u2010cell analyses. Talniflumate and ABT\u2010737 were predicted as potential therapeutic agents using the CMap and validated through molecular docking and 100\u2010ns molecular dynamics simulations. This study establishes a mitochondria\u2010related diagnostic model for AP and identifies candidate therapeutic agents, offering novel insights into the molecular pathogenesis and targeted intervention of AP.<\/jats:p>","DOI":"10.1049\/syb2.70040","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T03:46:59Z","timestamp":1760586419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrative Analysis of Mitochondrial\u2010Related Genes Reveals Diagnostic Biomarkers and Therapeutic Targets in Acute Pancreatitis"],"prefix":"10.1049","volume":"19","author":[{"given":"Yun","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Dalian Medical University  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Wan","sequence":"additional","affiliation":[{"name":"Clinical Laboratory 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