{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:44:35Z","timestamp":1782963875705,"version":"3.54.5"},"reference-count":37,"publisher":"Institution of Engineering and Technology (IET)","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ietresearch.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IET Systems Biology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Mitochondrial Fission Regulator 1 (\n                    <jats:italic>MTFR1<\/jats:italic>\n                    ) plays a critical regulatory role in various malignancies; however, its specific function and clinical significance in breast cancer (BRCA) remain unexplored. This study systematically characterised\n                    <jats:italic>MTFR1<\/jats:italic>\n                    by integrating multi\u2010omics data, spatial transcriptomics, and single\u2010cell sequencing, followed by in vitro experimental validation.\n                    <jats:italic>MTFR1<\/jats:italic>\n                    was significantly overexpressed in BRCA tissues and predominantly localised to malignant cells. Functionally,\n                    <jats:italic>MTFR1<\/jats:italic>\n                    was closely associated with cell cycle progression; in vitro knockdown significantly suppressed cell proliferation and induced cell cycle arrest. Clinically, high\n                    <jats:italic>MTFR1<\/jats:italic>\n                    expression served as an independent predictor of poor prognosis and was linked to chemotherapy resistance. Cross\u2010cancer immunotherapy analyses revealed that\n                    <jats:italic>MTFR1<\/jats:italic>\n                    exhibited improved predictive performance for anti\u2010PD\u20101 response during the on\u2010treatment phase compared with pretreatment settings. This study elucidates the multidimensional role of\n                    <jats:italic>MTFR1<\/jats:italic>\n                    as a putative oncogene in BRCA, highlighting it as a promising prognostic biomarker and therapeutic target.\n                  <\/jats:p>","DOI":"10.1049\/syb2.70080","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:58:47Z","timestamp":1782961127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of\n                    <i>MTFR1<\/i>\n                    as a Novel Prognostic Biomarker and Putative Oncogene for Breast Cancer: A Multi\u2010Omics Analysis and in Vitro Experimental Validation"],"prefix":"10.1049","volume":"20","author":[{"given":"Ya","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine North Sichuan Medical College  Nanchong Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of General Practice Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4338-9370","authenticated-orcid":false,"given":"Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Practice Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"265","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010022\u201001236\u20100"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010025\u201008072\u20103"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010025\u201002456\u2010x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2025.101288"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2025.189471"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010025\u201007078\u2010x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114727"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0281094"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2025.101159"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12033\u2010021\u201000445\u20101"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205338"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.771824"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac959"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010020\u201002116\u2010x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.can\u201018\u20100689"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.03.023"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.can\u201022\u20102682"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.can\u201023\u20102650"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201036560\u20107"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1007"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky939"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2021.100141"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.12.019"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100136\u20101"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.034"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.7554\/elife.71880"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22279"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44318\u2010024\u201000028\u20101"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/pgpm.s386085"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.348"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20126"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218989"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.832517"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaf009"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010024\u201003338\u2010z"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaf289"}],"container-title":["IET Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ietresearch.onlinelibrary.wiley.com\/doi\/pdf\/10.1049\/syb2.70080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ietresearch.onlinelibrary.wiley.com\/doi\/full-xml\/10.1049\/syb2.70080","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ietresearch.onlinelibrary.wiley.com\/doi\/pdf\/10.1049\/syb2.70080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:58:50Z","timestamp":1782961130000},"score":1,"resource":{"primary":{"URL":"https:\/\/ietresearch.onlinelibrary.wiley.com\/doi\/10.1049\/syb2.70080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1049\/syb2.70080"],"URL":"https:\/\/doi.org\/10.1049\/syb2.70080","archive":["Portico"],"relation":{},"ISSN":["1751-8849","1751-8857"],"issn-type":[{"value":"1751-8849","type":"print"},{"value":"1751-8857","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70080"}}