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Augmented reality (AR) is a promising tool to conveniently provide needed information and may thus overcome the limitations of existing approaches. To this end, a prototypical AR application was developed to guide the insertion of needles to spinal targets using the mixed reality glasses Microsoft HoloLens. The system's registration accuracy was attempted to measure and three guidance visualisation concepts were evaluated concerning achievable in\u2010plane and out\u2010of\u2010plane needle orientation errors in a comparison study. Results suggested high registration accuracy and showed that the AR prototype is suitable for reducing out\u2010of\u2010plane orientation errors. Limitations, like comparatively high in\u2010plane orientation errors, effects of the viewing position and missing image slices indicate potential for improvement that needs to be addressed before transferring the application to clinical trials.<\/jats:p>","DOI":"10.1049\/htl.2019.0062","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T22:21:49Z","timestamp":1570746109000},"page":"165-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["HoloInjection: augmented reality support for CT\u2010guided spinal needle injections"],"prefix":"10.1049","volume":"6","author":[{"given":"Florian","family":"Heinrich","sequence":"first","affiliation":[{"name":"Faculty of Computer Science University of Magdeburg  Universit\u00e4tsplatz 2 39106 Magdeburg Germany"},{"name":"Research Campus STIMULATE  Sandtorstrasse 23 39106 Magdeburg Germany"}]},{"given":"Luisa","family":"Schwenderling","sequence":"additional","affiliation":[{"name":"Faculty of Computer Science University of Magdeburg  Universit\u00e4tsplatz 2 39106 Magdeburg Germany"},{"name":"Research Campus STIMULATE  Sandtorstrasse 23 39106 Magdeburg Germany"}]},{"given":"Mathias","family":"Becker","sequence":"additional","affiliation":[{"name":"Research Campus STIMULATE  Sandtorstrasse 23 39106 Magdeburg Germany"},{"name":"Department of Neuroradiology University Hospital Magdeburg  Leipziger Strasse 44 39120 Magdeburg Germany"}]},{"given":"Martin","family":"Skalej","sequence":"additional","affiliation":[{"name":"Research Campus STIMULATE  Sandtorstrasse 23 39106 Magdeburg Germany"},{"name":"Department of Neuroradiology University Hospital Magdeburg  Leipziger Strasse 44 39120 Magdeburg Germany"}]},{"given":"Christian","family":"Hansen","sequence":"additional","affiliation":[{"name":"Faculty of Computer Science University of Magdeburg  Universit\u00e4tsplatz 2 39106 Magdeburg Germany"},{"name":"Research Campus STIMULATE  Sandtorstrasse 23 39106 Magdeburg Germany"}]}],"member":"265","published-online":{"date-parts":[[2019,11,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.08.1569"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1808\u2010185120171602163165"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002340000433"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/10929088.2011.597566"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.15.15803"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2012.10.028"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcs.261"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11548\u2010011\u20100660\u20107"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2401040018"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.6918"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1109\/TVCG.2019.2903942"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11548\u2010015\u20101156\u20107"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1049\/htl.2018.5076"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1109\/LRA.2018.2863381"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg\u20102017\u2010013649"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000478"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2013.2275741"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","unstructured":"Huang L. 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