{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:55:52Z","timestamp":1790636152212,"version":"4.1.0"},"reference-count":57,"publisher":"China Medical University","issue":"2","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMedicine"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Background: Osteoarthritis is a syndrome characterized by joint pain and reduced performance and efficien- cy in patient. <jats:italic>Thymus daenensis<\/jats:italic> has been used since old times for the treatment of bone and joint deformities and pain in traditional medicine.<\/jats:p>\n<jats:p>Purpose: This study was conducted to examine traditional usages and pharmacological features of <jats:italic>T. daen- ensis<\/jats:italic> with respect to the effect of the plant in patients with osteoarthritis.<\/jats:p>\n<jats:p>Methods: 120 patients with osteoarthritis were divided into 3 groups. Patients in each group were treated by 5% <jats:italic>Thymus daenensis<\/jats:italic> gel, 1% diclofenac gel, or placebo for 6 weeks, along with oral celecoxib capsules. Patients were assessed in different intervals, based on the VAS score for assessment of pain in the joint and different dimensions of WOMAC questionnaire.<\/jats:p>\n<jats:p>Results: Pain level (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.005), stiffness during the day (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), morning stiffness (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and physi- cal performance (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) were significantly different among the groups.<\/jats:p>\n<jats:p>Conclusions: <jats:italic>Thymus daenensis<\/jats:italic> gel improves the symptoms in patients equal and without significant difference than diclofenac group. It can be argued that its use can produce a satisfactory effect on patients with osteoarthritis due to its low cost, easy access, the plant\u2019s natively occurring in Iran.<\/jats:p>","DOI":"10.1051\/bmdcn\/2019090209","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T07:48:21Z","timestamp":1558684101000},"page":"9","source":"Crossref","is-referenced-by-count":17,"title":["Comparative study of the effect of Thymus daenensis gel 5% and diclofenac in patients with knee osteoarthritis"],"prefix":"10.37796","volume":"9","author":[{"given":"Morteza","family":"Dehghan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin","family":"Asgharian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Khalesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Lorigooini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"12796","published-online":{"date-parts":[[2019,5,24]]},"reference":[{"key":"R1","first-page":"766","volume":"24","author":"Altman","year":"1997","journal-title":"J Rheumatol."},{"key":"R2","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.joca.2011.08.009","volume":"19","author":"Pereira","year":"2011","journal-title":"Osteoarthr Cartil"},{"key":"R3","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1136\/ard.62.7.644","volume":"62","author":"Picavet","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"R4","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/1529-0131(199805)41:5<778::AID-ART4>3.0.CO;2-V","volume":"41","author":"Lawrence","year":"1998","journal-title":"Arthritis Rheum"},{"key":"R5","first-page":"646","volume":"81","author":"Woolf","year":"2003","journal-title":"Bull. 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