{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:17:46Z","timestamp":1790777866873,"version":"4.1.0"},"reference-count":56,"publisher":"EDP Sciences","issue":"1-2","license":[{"start":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T00:00:00Z","timestamp":1540512000000},"content-version":"vor","delay-in-days":298,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biologie Aujourd'hui"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>La s\u00e9cheresse oculaire est un des premiers motifs de consultation en ophtalmologie. Sa pr\u00e9valence varie de 5 \u00e0 35\u2009% chez des sujets \u00e2g\u00e9s de plus de 50\u2009ans. Cette pathologie du segment ant\u00e9rieur de l\u2019\u0153il est caract\u00e9ris\u00e9e par des sensations de douleurs variables dans leur intensit\u00e9, allant du simple inconfort \u00e0 une douleur oculaire prononc\u00e9e. Les douleurs oculaires sont tr\u00e8s invalidantes et difficiles \u00e0 traiter et leurs m\u00e9canismes physiopathologiques demeurent de nos jours mal connus. Ce constat impose un approfondissement de nos connaissances fondamentales sur l\u2019anatomie du syst\u00e8me nociceptif corn\u00e9en et sur les m\u00e9canismes cellulaires impliqu\u00e9s dans l\u2019initiation et la chronicisation de la douleur oculaire. Cette revue pr\u00e9sente dans une premi\u00e8re partie l\u2019anatomie et la physiologie de l\u2019innervation corn\u00e9enne et les diff\u00e9rentes classes de r\u00e9cepteurs corn\u00e9ens ainsi que les structures centrales mises en jeu dans la transmission du message nociceptif. La seconde partie fait un \u00e9tat des lieux des donn\u00e9es pr\u00e9cliniques et cliniques sur les m\u00e9canismes inflammatoires et neuro-inflammatoires qui ont \u00e9t\u00e9 identifi\u00e9s lors de douleurs corn\u00e9ennes. Enfin, la derni\u00e8re partie de cette revue d\u00e9crit les diff\u00e9rents dispositifs actuellement utilis\u00e9s pour \u00e9valuer la douleur et l\u2019inflammation oculaire en clinique humaine.<\/jats:p>","DOI":"10.1051\/jbio\/2018017","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T04:00:45Z","timestamp":1540526445000},"page":"1-11","source":"Crossref","is-referenced-by-count":9,"title":["Vers une meilleure compr\u00e9hension des douleurs oculaires chroniques"],"prefix":"10.1051","volume":"212","author":[{"given":"St\u00e9phane","family":"Melik Parsadaniantz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Rost\u00e8ne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Baudouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle","family":"R\u00e9aux-Le Goazigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2018,10,26]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1016\/j.pain.2013.07.012","volume":"154","author":"Acosta","year":"2013","journal-title":"Pain"},{"key":"R2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jtos.2015.01.005","volume":"13","author":"Aggarwal","year":"2015","journal-title":"Ocul Surf"},{"key":"R3","unstructured":"Alcalde, I., Inigo-Portugues, A., Gonzalez-Gonzalez, O., Almaraz, L., Artime, E., Morenilla-Palao, C., Gallar, J., Viana, F., Merayo-Lloves, J., Belmonte, C. (2018). Morphological and functional changes in TRPM8-expressing corneal cold thermoreceptor neurons during aging and their impact on tearing in mice. J Comp Neurol, doi: 10.1002."},{"key":"R4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/ICL.0b013e3181c739ad","volume":"36","author":"Asbell","year":"2010","journal-title":"Eye Contact Lens"},{"key":"R5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0181-5512(08)71431-1","volume":"31","author":"Baudouin","year":"2008","journal-title":"J Fr Ophtalmol"},{"key":"R6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.preteyeres.2010.03.001","volume":"29","author":"Baudouin","year":"2010","journal-title":"Prog Retin Eye Res"},{"key":"R7","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S1542-0124(12)70112-X","volume":"2","author":"Belmonte","year":"2004","journal-title":"Ocul Surf"},{"key":"R8","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.exer.2003.09.023","volume":"78","author":"Belmonte","year":"2004","journal-title":"Exp Eye Res"},{"key":"R9","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1167\/iovs.09-5119","volume":"52","author":"Belmonte","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s40135-015-0073-9","volume":"3","author":"Belmonte","year":"2015","journal-title":"Curr Ophthalmol Rep"},{"key":"R11","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jtos.2017.05.002","volume":"15","author":"Belmonte","year":"2017","journal-title":"Ocul Surf"},{"key":"R12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.exer.2003.08.005","volume":"78","author":"Brignole-Baudouin","year":"2004","journal-title":"Exp Eye Res"},{"key":"R13","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1002\/cne.23560","volume":"522","author":"Bron","year":"2014","journal-title":"J Comp Neurol"},{"key":"R14","doi-asserted-by":"crossref","unstructured":"Callejo, G., Castellanos, A., Castany, M., Gual, A., Luna, C., Acosta, M.C., Gallar, J., Giblin, J.P., Gasull, X. (2015). Acid-sensing ion channels detect moderate acidifications to induce ocular pain. Pain, 156, 483-495.","DOI":"10.1097\/01.j.pain.0000460335.49525.17"},{"key":"R15","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/nn.3144","volume":"15","author":"Chiu","year":"2012","journal-title":"Nat Neurosci"},{"key":"R16","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1051\/medsci\/2003195567","volume":"19","author":"Dallel","year":"2003","journal-title":"Med Sci (Paris)"},{"key":"R17","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/j.1532-2149.2013.00377.x","volume":"18","author":"Dauvergne","year":"2013","journal-title":"Eur J Pain"},{"key":"R18","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1046\/j.1460-9568.1999.00498.x","volume":"11","author":"De Felipe","year":"1999","journal-title":"Eur J Neurosci"},{"key":"R19","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1750-3639.2011.00485.x","volume":"21","author":"Dosa","year":"2011","journal-title":"Brain Pathol"},{"key":"R20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainresprot.2005.10.003","volume":"16","author":"Farazifard","year":"2005","journal-title":"Brain Res Brain Res Protoc"},{"key":"R21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1090-3801(99)90186-6","volume":"3","author":"Felipe","year":"1999","journal-title":"Eur J Pain"},{"key":"R22","doi-asserted-by":"crossref","first-page":"6289","DOI":"10.1167\/iovs.14-13984","volume":"55","author":"Ferrari","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R23","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/S0161-6420(03)00486-X","volume":"110","author":"Gabison","year":"2003","journal-title":"Ophthalmology"},{"key":"R24","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1113\/jphysiol.1993.sp019791","volume":"468","author":"Gallar","year":"1993","journal-title":"J Physiol"},{"key":"R25","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1167\/iovs.07-0012","volume":"48","author":"Gallar","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R26","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1167\/iovs.16-20033","volume":"58","author":"Gonzalez-Gonzalez","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R27","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/08820538.2015.1114853","volume":"31","author":"Goyal","year":"2016","journal-title":"Semin Ophthalmol"},{"key":"R28","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nri3621","volume":"14","author":"Grace","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"R29","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jtos.2016.10.002","volume":"15","author":"Hamrah","year":"2017","journal-title":"Ocul Surf"},{"key":"R30","doi-asserted-by":"crossref","unstructured":"Hegarty D.M., Hermes S.M., Morgan M.M., Aicher S.A. (2018). Acute hyperalgesia and delayed dry eye after corneal abrasion injury, Bioarchive, doi: https:\/\/doi.org\/10.1101\/242685.","DOI":"10.1101\/242685"},{"key":"R31","doi-asserted-by":"crossref","first-page":"5821","DOI":"10.1167\/iovs.14-14642","volume":"55","author":"Hirata","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R32","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/cne.23207","volume":"521","author":"Ivanusic","year":"2013","journal-title":"J Comp Neurol"},{"key":"R33","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1006\/exer.1997.0446","volume":"66","author":"Jones","year":"1998","journal-title":"Exp Eye Res"},{"key":"R34","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.neuroscience.2015.01.046","volume":"290","author":"Katagiri","year":"2015","journal-title":"Neuroscience"},{"key":"R35","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/j.pain.0000000000000455","volume":"157","author":"Kovacs","year":"2016","journal-title":"Pain"},{"key":"R36","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/ICO.0b013e3181bd44ce","volume":"29","author":"Labbe","year":"2010","journal-title":"Cornea"},{"key":"R37","doi-asserted-by":"crossref","first-page":"5144","DOI":"10.1167\/iovs.13-12370","volume":"54","author":"Labbe","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R38","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.exer.2015.06.008","volume":"139","author":"Launay","year":"2015","journal-title":"Exp Eye Res"},{"key":"R39","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.nbd.2015.12.017","volume":"88","author":"Launay","year":"2016","journal-title":"Neurobiol Dis"},{"key":"R40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/exer.1997.0312","volume":"65","author":"May","year":"1997","journal-title":"Exp Eye Res"},{"key":"R41","doi-asserted-by":"crossref","unstructured":"McLaughlin, C.R., Acosta, M.C., Luna, C., Liu, W., Belmonte, C., Griffith, M., Gallar, J. (2010). Regeneration of functional nerves within full thickness collagen-phosphorylcholine corneal substitute implants in guinea pigs. Biomaterials, 31, 2770-2778.","DOI":"10.1016\/j.biomaterials.2009.12.031"},{"key":"R42","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nrn3858","volume":"16","author":"Melik Parsadaniantz","year":"2015","journal-title":"Nat Rev Neurosci"},{"key":"R43","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0306-4522(95)00541-2","volume":"72","author":"Meng","year":"1996","journal-title":"Neuroscience"},{"key":"R44","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0014-4835(03)00050-2","volume":"76","author":"Muller","year":"2003","journal-title":"Exp Eye Res"},{"key":"R45","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.3390\/ijms19041221","volume":"19","author":"Nicolle","year":"2018","journal-title":"Int J Mol Sci"},{"key":"R46","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.exer.2009.11.018","volume":"90","author":"Panneton","year":"2010","journal-title":"Exp Eye Res"},{"key":"R47","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jpain.2006.09.005","volume":"8","author":"Price","year":"2007","journal-title":"J Pain"},{"key":"R48","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.ophtha.2016.03.006","volume":"123","author":"Qazi","year":"2016","journal-title":"Ophthalmology"},{"key":"R49","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1097\/j.pain.0000000000000135","volume":"156","author":"Rahman","year":"2015","journal-title":"Pain"},{"key":"R50","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1051\/medsci\/20173308020","volume":"33","author":"R\u00e9aux-Le Goazigo","year":"2017","journal-title":"Med Sci (Paris)"},{"key":"R51","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jtos.2012.01.002","volume":"10","author":"Rosenthal","year":"2012","journal-title":"Ocul Surf"},{"key":"R52","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1136\/bjophthalmol-2014-306280","volume":"100","author":"Rosenthal","year":"2016","journal-title":"Br J Ophthalmol"},{"key":"R53","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/nn1992","volume":"10","author":"Scholz","year":"2007","journal-title":"Nat Neurosci"},{"key":"R54","doi-asserted-by":"crossref","unstructured":"Stapleton, F., Marfurt, C., Golebiowski, B., Rosenblatt, M., Bereiter, D., Begley, C., Dartt, D., Gallar, J., Belmonte, C., Hamrah, P., Willcox, M., Discomfort, T.I.W.o.C.L. (2013). The TFOS International Workshop on Contact Lens Discomfort: report of the subcommittee on neurobiology. Invest Ophthalmol Vis Sci, 54, TFOS71-97.","DOI":"10.1167\/iovs.13-13226"},{"key":"R55","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1089\/can.2017.0041","volume":"3","author":"Thapa","year":"2018","journal-title":"Cannabis Cannabinoid Res"},{"key":"R56","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbi.2014.10.016","volume":"45","author":"Van Steenwinckel","year":"2015","journal-title":"Brain Behav Immun"}],"container-title":["Biologie Aujourd'hui"],"original-title":[],"link":[{"URL":"https:\/\/www.biologie-journal.org\/10.1051\/jbio\/2018017\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T15:59:38Z","timestamp":1720713578000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biologie-journal.org\/10.1051\/jbio\/2018017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":56,"journal-issue":{"issue":"1-2"},"alternative-id":["jbio180017"],"URL":"https:\/\/doi.org\/10.1051\/jbio\/2018017","relation":{},"ISSN":["2105-0678","2105-0686"],"issn-type":[{"value":"2105-0678","type":"print"},{"value":"2105-0686","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}