{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T07:29:31Z","timestamp":1648711771858},"reference-count":20,"publisher":"EDP Sciences","issue":"3-4","license":[{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"vor","delay-in-days":345,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biologie Aujourd\u2019hui"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>L\u2019addiction est une maladie chronique qui engendre de lourdes cons\u00e9quences, \u00e0 la fois en termes de sant\u00e9 publique et au niveau \u00e9conomique. Des caract\u00e9ristiques claires distinguent bien l\u2019usage r\u00e9cr\u00e9atif et contr\u00f4l\u00e9, de l\u2019addiction. Ainsi, aujourd\u2019hui, l\u2019addiction inclut les notions de recherche compulsive de la drogue, associ\u00e9es \u00e0 une perte de contr\u00f4le sur sa prise, favorisant l\u2019\u00e9mergence d\u2019un d\u00e9sir persistant et irr\u00e9pressible pour la drogue (appel\u00e9 <jats:italic>craving<\/jats:italic>). \u00c0 l\u2019arr\u00eat de la consommation, des sympt\u00f4mes de sevrage peuvent \u00e9merger\u2009: un \u00e9tat \u00e9motionnel n\u00e9gatif, des troubles cognitifs et des sympt\u00f4mes physiques avec certains produits (alcool et opiac\u00e9s, par exemple). Les \u00e9pisodes de rechute peuvent survenir au cours de cette p\u00e9riode de sevrage pour contrer les effets n\u00e9gatifs du sevrage. De tels \u00e9pisodes peuvent aussi \u00eatre observ\u00e9s apr\u00e8s de longues p\u00e9riodes d\u2019abstinence. Ils peuvent \u00eatre pr\u00e9cipit\u00e9s par une r\u00e9exposition au contexte dans lequel les prises de drogues s\u2019effectuaient, ou encore par un stress. Quel que soit le stade auquel on se place (<jats:italic>e.g<\/jats:italic>., mise en place de l\u2019addiction, ou rechute), des changements dans les fonctions et la structure du cerveau peuvent \u00eatre observ\u00e9s. Certaines structures c\u00e9r\u00e9brales sont donc modifi\u00e9es, comme le cortex pr\u00e9frontal, o\u00f9 plusieurs neuroadaptations ont \u00e9t\u00e9 mises en \u00e9vidence. Certaines de ces modifications sont revisit\u00e9es dans cet article.<\/jats:p>","DOI":"10.1051\/jbio\/2019013","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T09:00:17Z","timestamp":1576141217000},"page":"141-145","source":"Crossref","is-referenced-by-count":0,"title":["Circuits neuronaux et neurom\u00e9diateurs impliqu\u00e9s dans les effets des drogues psychoactives\u2009\u2013\u2009\u00c9tat de l\u2019art avec un focus sur la coca\u00efne"],"prefix":"10.1051","volume":"213","author":[{"given":"Florence","family":"Noble","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2019,12,12]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.282.5387.298","volume":"282","author":"Ahmed","year":"1998","journal-title":"Science"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Geoffroy H.A.-S., \nPuig S., 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