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Les effets subjectifs et comportementaux qu\u2019ils induisent sont tr\u00e8s impressionnants, et malgr\u00e9 leur toxicit\u00e9 potentielle, le risque d\u2019addiction est relativement faible par rapport \u00e0 la nicotine, l\u2019alcool ou les opiac\u00e9s. Depuis la d\u00e9couverte des effets antid\u00e9presseurs de la k\u00e9tamine, il existe un regain d\u2019int\u00e9r\u00eat pour cette classe de mol\u00e9cules. En effet, la psilocybine et l\u2019acide lysergique di\u00e9thylamide (LSD) gagnent de la popularit\u00e9 en tant que traitement pour la d\u00e9pression et l\u2019addiction, la 3,4-m\u00e9thyl\u00e8nedioxym\u00e9thamph\u00e9tamine (MDMA) pour l\u2019\u00e9tat de stress post-traumatique, et l\u2019iboga\u00efne pour l\u2019addiction. Malgr\u00e9 des profils pharmacologiques distincts, ces diff\u00e9rentes drogues partagent une cin\u00e9tique d\u2019action similaire\u2009: leurs effets th\u00e9rapeutiques se font ressentir dans les heures suivant l\u2019administration et perdurent au-del\u00e0 de leur \u00e9limination par l\u2019organisme. Ceci sugg\u00e8re des m\u00e9canismes plastiques et neurog\u00e9niques impliquant entre autres des facteurs trophiques. Cette revue explorera la litt\u00e9rature concernant les effets de ces diff\u00e9rents compos\u00e9s sur les neurotrophines, ainsi que les adaptations plastiques qui sont mises en place dans les heures et jours suivant l\u2019administration, afin de comprendre leur potentiel th\u00e9rapeutique \u00e9tonnant.<\/jats:p>","DOI":"10.1051\/jbio\/2019015","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T09:00:17Z","timestamp":1576141217000},"page":"121-129","source":"Crossref","is-referenced-by-count":6,"title":["Utilisation des psych\u00e9d\u00e9liques en psychiatrie\u2009: lien avec les 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