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Outre son r\u00f4le primordial dans la d\u00e9gradation des prot\u00e9ines, il intervient aussi dans l\u2019adressage, la signalisation ou la r\u00e9paration de l\u2019ADN, ce qui en fait un acteur incontournable de l\u2019hom\u00e9ostasie cellulaire. Bien que d\u2019autres syst\u00e8mes de contr\u00f4les existent dans la cellule, l\u2019UPS est souvent consid\u00e9r\u00e9 comme le chef d\u2019orchestre. Au vu de son importance, toute d\u00e9r\u00e9gulation de l\u2019UPS entra\u00eene des d\u00e9sordres plus ou moins s\u00e9v\u00e8res pour la cellule et donc l\u2019organisme. De fait, l\u2019UPS est impliqu\u00e9 dans de nombreuses pathologies (cancer, maladie d\u2019Alzheimer, de Huntington, etc.). L\u2019UPS est compos\u00e9 de plus de 1000 prot\u00e9ines diff\u00e9rentes dont les combinaisons permettent le ciblage fin de virtuellement toutes les prot\u00e9ines de l\u2019organisme. L\u2019UPS fait appel \u00e0 une cascade enzymatique (E1, 2 isoformes\u2009; E2 &gt;\u200935 isoformes\u2009; E3 &gt;\u2009800 isoformes) qui permet le transfert de l\u2019ubiquitine, une petite prot\u00e9ine de 8,5\u2009kDa, sur la prot\u00e9ine \u00e0 cibler soit pour sa d\u00e9gradation, soit pour modifier son activit\u00e9. Ce signal d\u2019ubiquitinylation est r\u00e9versible et de nombreuses d\u00e9ubiquitinylases (DUB, \u223c\u200980 isoformes) jouent aussi un r\u00f4le important. Les enzymes E3 sont les plus nombreuses et leur fonction est de reconna\u00eetre la prot\u00e9ine cible, ce qui en fait des acteurs importants dans la sp\u00e9cificit\u00e9 d\u2019action de l\u2019UPS. La nature m\u00eame des E3 et la complexit\u00e9 de leurs interactions avec diff\u00e9rents partenaires offrent un champ d\u2019investigation tr\u00e8s large et donc des potentialit\u00e9s importantes pour le d\u00e9veloppement d\u2019approches th\u00e9rapeutiques. Sans \u00eatre exhaustive, cette revue illustre les diff\u00e9rentes strat\u00e9gies ayant d\u00e9j\u00e0 \u00e9t\u00e9 mises en \u0153uvre pour lutter contre diff\u00e9rentes pathologies (\u00e0 l\u2019exclusion des infections bact\u00e9riennes ou virales).<\/jats:p>","DOI":"10.1051\/jbio\/2021006","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T07:56:12Z","timestamp":1629100572000},"page":"45-57","source":"Crossref","is-referenced-by-count":2,"title":["Contr\u00f4le des voies m\u00e9taboliques par les enzymes E3 ligases\u2009: une opportunit\u00e9 de ciblage 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https:\/\/doi.org\/10.1242\/jcs.228072.","DOI":"10.1242\/jcs.228072"},{"key":"R113","doi-asserted-by":"crossref","first-page":"17677","DOI":"10.1002\/chem.201804169","volume":"24","author":"Watt","year":"2018","journal-title":"Chemistry"},{"key":"R114","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3389\/fphys.2019.00370","volume":"10","author":"Weber","year":"2019","journal-title":"Front Physiol"},{"key":"R115","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1042\/BJ20100985","volume":"433","author":"Wenzel","year":"2011","journal-title":"Biochem J"},{"key":"R116","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/cdd.2017.33","volume":"24","author":"Witt","year":"2017","journal-title":"Cell Death Differ"},{"key":"R117","doi-asserted-by":"crossref","first-page":"E2011","DOI":"10.1073\/pnas.1601089113","volume":"113","author":"Wu","year":"2016","journal-title":"Proc Natl Acad Sci 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