{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:31:24Z","timestamp":1767652284523},"reference-count":21,"publisher":"EDP Sciences","issue":"1-2","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":205,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biologie Aujourd\u2019hui"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>Si les sympt\u00f4mes du diab\u00e8te ont \u00e9t\u00e9 d\u00e9crits depuis l\u2019Antiquit\u00e9 et caract\u00e9ris\u00e9s par la pr\u00e9sence de sucre dans les urines et une soif intense, ce n\u2019est qu\u2019\u00e0 la fin du <jats:sc>xix<\/jats:sc><jats:sup>e<\/jats:sup> si\u00e8cle que les travaux de plusieurs \u00e9quipes aboutissent \u00e0 rechercher la substance active de la s\u00e9cr\u00e9tion interne du pancr\u00e9as dans des extraits susceptibles de diminuer le glucose dans le sang et les urines chez le chien diab\u00e9tique. C\u2019est \u00e0 l\u2019Universit\u00e9 de Toronto, au Canada, il y a 100 ans, entre 1921 et 1922, que Frederick Banting, Charles Best et James Collip, travaillant dans le d\u00e9partement de physiologie dirig\u00e9 par John MacLeod, obtiennent des extraits pancr\u00e9atiques suffisamment purifi\u00e9s qui permettent de traiter de jeunes patients diab\u00e9tiques. Cette d\u00e9couverte de l\u2019insuline est tr\u00e8s vite reconnue et salu\u00e9e par l\u2019attribution du Prix Nobel de Physiologie ou M\u00e9decine en 1923 \u00e0 Frederick Banting et John MacLeod. Cette d\u00e9couverte a eu d\u2019importantes retomb\u00e9es scientifiques, industrielles et cliniques, toujours d\u2019actualit\u00e9.<\/jats:p>","DOI":"10.1051\/jbio\/2022006","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T07:51:53Z","timestamp":1658735513000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["La d\u00e9couverte de l\u2019insuline 1921\u20131922 : un saut dans la recherche biom\u00e9dicale"],"prefix":"10.1051","volume":"216","author":[{"given":"William","family":"Rost\u00e8ne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"R1","first-page":"256","volume":"7","author":"Banting","year":"1922","journal-title":"J Lab Clin Med"},{"key":"R2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1152\/ajplegacy.1922.62.1.162","volume":"62","author":"Banting","year":"1922","journal-title":"Am J Physiol"},{"key":"R3","first-page":"141","volume":"12","author":"Banting","year":"1922","journal-title":"Can Med Assoc J"},{"key":"R4","first-page":"437","volume":"31","author":"Barron","year":"1920","journal-title":"Surg Gynecol Obstet,"},{"key":"R5","first-page":"1","volume":"9","author":"Bernard","year":"1867","journal-title":"CR Soc Biol,"},{"key":"R6","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0021-9258(18)85482-5","volume":"23","author":"Best","year":"1923","journal-title":"J Biol Chem,"},{"key":"R7","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1126\/science.85.2205.338","volume":"85","author":"Best","year":"1937","journal-title":"Science,"},{"key":"R8","unstructured":"Bliss M. 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(1912). Pancreas preparation suitable for the treatment of diabetes. US Patent Office, May 28, No. 431.226."}],"container-title":["Biologie Aujourd\u2019hui"],"original-title":[],"link":[{"URL":"https:\/\/www.biologie-journal.org\/10.1051\/jbio\/2022006\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T12:00:05Z","timestamp":1666958405000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biologie-journal.org\/10.1051\/jbio\/2022006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":21,"journal-issue":{"issue":"1-2"},"alternative-id":["jbio220006"],"URL":"https:\/\/doi.org\/10.1051\/jbio\/2022006","relation":{},"ISSN":["2105-0678","2105-0686"],"issn-type":[{"value":"2105-0678","type":"print"},{"value":"2105-0686","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}