{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T01:03:28Z","timestamp":1701306208762},"reference-count":26,"publisher":"EDP Sciences","issue":"3-4","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":332,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biologie Aujourd\u2019hui"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Le curare, un poison obtenu \u00e0 partir de diff\u00e9rentes esp\u00e8ces de plantes en Am\u00e9rique du Sud, \u00e9tait utilis\u00e9 sur les fl\u00e8ches par les autochtones. Son potentiel paralysant mortel et son m\u00e9canisme d\u2019action ont commenc\u00e9 \u00e0 \u00eatre explor\u00e9s par les chercheurs au XIX<jats:sup>e<\/jats:sup> si\u00e8cle. Dans cet article, nous rappelons l\u2019historique des recherches sur ce poison et les \u00e9changes entre l\u2019empereur br\u00e9silien Dom Pedro II et les chercheurs Jo\u00e3o Baptista de Lacerda, Louis Couty et Alfred Vulpian qui ont beaucoup contribu\u00e9 au d\u00e9veloppement scientifique br\u00e9silien. Vulpian a d\u00e9couvert que le curare n\u2019affecte pas le nerf lui-m\u00eame, mais agit entre celui-ci et le muscle, par l\u2019interm\u00e9diaire d\u2019une \u00ab\u00a0substance de liaison\u00a0\u00bb\u2009\u2013\u2009ce concept d\u00e9velopp\u00e9 par Vulpian est souvent attribu\u00e9 \u00e0 tort \u00e0 Claude Bernard. Les travaux pionniers de ces savants prestigieux ont ult\u00e9rieurement abouti \u00e0 la pr\u00e9paration d\u2019extrait purifi\u00e9 de curare, d\u2019int\u00e9r\u00eat th\u00e9rapeutique majeur pour le traitement de convulsions et pour l\u2019anesth\u00e9sie.<\/jats:p>","DOI":"10.1051\/jbio\/2023025","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T09:01:28Z","timestamp":1701248488000},"page":"245-252","source":"Crossref","is-referenced-by-count":0,"title":["Importance des \u00e9tudes transnationales sur le curare dans le d\u00e9veloppement de la recherche en neurophysiologie au Br\u00e9sil"],"prefix":"10.1051","volume":"217","author":[{"given":"Roberto","family":"Pereira Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Eg\u00eddio","family":"Nardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marleide","family":"da Mota Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1051\/jbio:2009026","volume":"203","author":"Barbara","year":"2009","journal-title":"J Soc Biol"},{"key":"R2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.brainres.2011.06.009","volume":"1409","author":"Barbara","year":"2011","journal-title":"Brain Res"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Benchimol J.L. (1999). Dos micr\u00f3bios aos mosquitos: febre amarela e revolu\u00e7\u00e3o pasteuriana no Brasil. Rio de Janeiro: FIOCRUZ\/UFRJ, pp.\u2009169-172.","DOI":"10.7476\/9788575413166"},{"key":"R4","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1213\/00000539-196809000-00007","volume":"47","author":"Bennett","year":"1968","journal-title":"Anesth Analg"},{"key":"R5","first-page":"825","volume":"43","author":"Bernard","year":"1856","journal-title":"C R Acad Sci (Paris)"},{"key":"R6","first-page":"219","volume":"34","author":"Cousin","year":"2000","journal-title":"Hist Sci Med"},{"key":"R7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/00000542-200208000-00049","volume":"97","author":"Cousin","year":"2002","journal-title":"Anesthesiology"},{"key":"R8","unstructured":"Couty L. (date inconnue) Mem\u00f3rias cient\u00edficas. \u2013\u2009Em franc\u00eas. Nota sobre o estado do sistema nervoso dos macacos e outra sobre um curare extra\u00eddo de uma s\u00f3 planta. Carta a D. Pedro II, cedida pelo Museu Imperial, Petr\u00f3polis, Rio de Janeiro, Brasil. Ma\u00e7o 28\u2009\u2013Doc 997."},{"key":"R9","first-page":"582","volume":"89","author":"Couty","year":"1879","journal-title":"C R Acad Sci (Paris)"},{"key":"R10","first-page":"555","volume":"10","author":"Couty","year":"1880","journal-title":"Arch Physiol Norm Pathol"},{"key":"R11","unstructured":"Dicion\u00e1rio Hist\u00f3rico Biogr\u00e1fico das Ci\u00eancias da Sa\u00fade no Brasil (1832\u20131930)\u2009\u2013\u2009Laborat\u00f3rio de Fisiologia Experimental. Rio de Janeiro: Casa de Oswaldo Cruz, Fiocruz, 2010. Available from http:\/\/www.dichistoriasaude.coc.fiocruz.br\/iah\/pt\/pdf\/labfisexp.pdf."},{"key":"R12","first-page":"330","volume":"50","author":"Duarte","year":"2000","journal-title":"Rev Bras Anestesiol"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Gomes A.C.V. (2013). 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(1887). Louis Couty, esbo\u00e7o biogr\u00e1fico. In: Couty L., Pequena propriedade e imigra\u00e7\u00e3o europeia. Rio de Janeiro: Imprensa Nacional, pp.\u20097-29."},{"key":"R24","first-page":"25","volume":"11","author":"Vulpian","year":"1857","journal-title":"L\u2019Union Medicale"},{"key":"R25","unstructured":"Vulpian E.F.A. (1866). Le\u00e7ons sur la physiologie g\u00e9n\u00e9rale et compar\u00e9e du syst\u00e8me nerveux, faites au Mus\u00e9um d\u2019histoire naturelle. Paris\u00a0: Gerner-Bailli\u00e8re, pp.\u2009207-226."},{"key":"R26","unstructured":"Vulpian E.F.A. (1882). Le\u00e7ons sur l\u2019action physiologique des substances toxiques et m\u00e9dicamenteuses. 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