{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T01:04:04Z","timestamp":1701306244404},"reference-count":26,"publisher":"EDP Sciences","issue":"3-4","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":332,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biologie Aujourd\u2019hui"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Les patients souffrant de d\u00e9pression suicidaire r\u00e9pondent moins bien aux traitements antid\u00e9presseurs conventionnels que ceux qui n\u2019ont pas d\u2019id\u00e9es suicidaires. Une avanc\u00e9e prometteuse dans ce domaine est l\u2019utilisation de la k\u00e9tamine, qui a montr\u00e9 une efficacit\u00e9 significative et rapide dans la r\u00e9duction de l\u2019intensit\u00e9 des id\u00e9es suicidaires chez les patients d\u00e9prim\u00e9s. Des \u00e9tudes ont montr\u00e9 qu\u2019une seule perfusion intraveineuse de k\u00e9tamine \u00e0 faible dose pouva3it r\u00e9duire de mani\u00e8re significative et durable les id\u00e9es de suicide. De plus, la k\u00e9tamine semble \u00e9galement r\u00e9duire l\u2019anh\u00e9donie, un sympt\u00f4me associ\u00e9 aux id\u00e9es suicidaires. Les m\u00e9canismes d\u2019action de la k\u00e9tamine sont multiples. Elle stimule la neuroplasticit\u00e9 <jats:italic>via<\/jats:italic> l\u2019activation de la voie du BDNF (facteur neurotrophique du cerveau) et r\u00e9duit l\u2019inflammation. De plus, la k\u00e9tamine semble agir sur le syst\u00e8me opio\u00efdergique, qui est impliqu\u00e9 dans les conduites suicidaires. En conclusion, la k\u00e9tamine pr\u00e9sente un int\u00e9r\u00eat dans la r\u00e9duction des id\u00e9es suicidaires chez les patients d\u00e9prim\u00e9s. Cependant, il est n\u00e9cessaire de d\u00e9terminer si son administration permet de pr\u00e9venir les actes suicidaires. De plus amples recherches sont n\u00e9cessaires pour mieux comprendre les m\u00e9canismes d\u2019action de la k\u00e9tamine et d\u00e9velopper des strat\u00e9gies th\u00e9rapeutiques cibl\u00e9es pour pr\u00e9venir les conduites suicidaires.<\/jats:p>","DOI":"10.1051\/jbio\/2023029","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T09:01:28Z","timestamp":1701248488000},"page":"157-160","source":"Crossref","is-referenced-by-count":0,"title":["Comment la k\u00e9tamine peut-elle aider \u00e0 mieux prendre en charge le risque suicidaire\u00a0?"],"prefix":"10.1051","volume":"217","author":[{"given":"Emilie","family":"Oli\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aist\u00e9","family":"Lengvenyte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Courtet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/13811110590929488","volume":"9","author":"Angst","year":"2005","journal-title":"Arch Suicide Res"},{"key":"R2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jad.2017.04.057","volume":"218","author":"Ballard","year":"2017","journal-title":"J Affect Disord"},{"key":"R3","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.neuropharm.2016.01.034","volume":"112","author":"Bryleva","year":"2017","journal-title":"Neuropharmacology"},{"key":"R4","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jad.2019.03.075","volume":"251","author":"Chen","year":"2019","journal-title":"J Affect Disord"},{"key":"R5","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bbi.2015.02.004","volume":"46","author":"Ducasse","year":"2015","journal-title":"Brain Behav Immun"},{"key":"R6","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/da.22709","volume":"35","author":"Ducasse","year":"2018","journal-title":"Depress Anxiety"},{"key":"R7","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1038\/s41380-019-0400-x","volume":"24","author":"Duman","year":"2019","journal-title":"Mol Psychiatry"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Dwivedi Y., Brain-derived neurotrophic factor in suicide pathophysiology, in: Dwivedi Y. 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