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Des dizaines d\u2019hormones ont \u00e9t\u00e9 d\u00e9crites et sont communes \u00e0 l\u2019ensemble des vert\u00e9br\u00e9s (certains messagers chimiquement proches ont \u00e9t\u00e9 \u00e9galement r\u00e9pertori\u00e9s chez les invert\u00e9br\u00e9s) avec des r\u00f4les variables et pas toujours connus. Les effets des PE concernent donc potentiellement toutes les esp\u00e8ces animales <jats:italic>via<\/jats:italic> tous les axes endocriniens\u00a0; ils s\u2019ajoutent aux autres param\u00e8tres de l\u2019exposome qui induisent une pression d\u2019adaptation forte, multiple, et difficile \u00e0 appr\u00e9hender. Les effets des PE sur les voies de la reproduction et les voies thyro\u00efdiennes sont parmi les plus \u00e9tudi\u00e9s depuis ces trente derni\u00e8res ann\u00e9es et ce, sur un grand nombre d\u2019esp\u00e8ces. L\u2019\u00e9tude des effets des PE sur les voies thyro\u00efdiennes ainsi que sur le d\u00e9veloppement c\u00e9r\u00e9bral va de pair avec l\u2019augmentation des connaissances sur 1) les diff\u00e9rents r\u00f4les des hormones thyro\u00efdiennes au niveau cellulaire ou tissulaire (notamment le tissu c\u00e9r\u00e9bral en d\u00e9veloppement) chez de nombreuses esp\u00e8ces, 2) les autres voies hormonales et 3) les interactions \u00e9pig\u00e9n\u00e9tiques. De fa\u00e7on g\u00e9n\u00e9rale, si l\u2019on veut appr\u00e9hender comment agissent les PE sur les organismes vivants, il est n\u00e9cessaire d\u2019analyser dans une approche int\u00e9gr\u00e9e et multi-mod\u00e8les (approche dite translationnelle) les r\u00e9sultats issus de domaines scientifiques compl\u00e9mentaires. Dans cette br\u00e8ve revue, nous dressons un \u00e9tat des lieux de d\u00e9couvertes r\u00e9centes et discutons les perspectives d\u2019action dans les champs de la m\u00e9decine et de la recherche. Nous mettons en avant la n\u00e9cessit\u00e9 d\u2019une approche int\u00e9gr\u00e9e et multidisciplinaire pour \u00e9tudier les impacts des PE et prendre des mesures appropri\u00e9es.<\/jats:p>","DOI":"10.1051\/jbio\/2023036","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T09:01:28Z","timestamp":1701248488000},"page":"219-231","source":"Crossref","is-referenced-by-count":0,"title":["Les perturbateurs des hormones thyro\u00efdiennes\u00a0: comment estimer leurs impacts sur la sant\u00e9 humaine et l\u2019environnement\u00a0?"],"prefix":"10.1051","volume":"217","author":[{"given":"Patricia","family":"Rannaud-Bartaire","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Baptiste","family":"Fini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1515\/hmbci-2020-0029","volume":"42","author":"Ababzadeh","year":"2020","journal-title":"Horm Mol Biol Clin Investig"},{"key":"R2","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1172\/JCI107286","volume":"52","author":"Abuid","year":"1973","journal-title":"J Clin Invest"},{"key":"R3","doi-asserted-by":"crossref","first-page":"5391","DOI":"10.1093\/bioinformatics\/btz570","volume":"35","author":"Aguayo-Orozco","year":"2019","journal-title":"Bioinform"},{"key":"R4","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1210\/en.2005-1058","volume":"147","author":"Anway","year":"2006","journal-title":"Endocrinology"},{"key":"R5","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.ajhg.2012.04.017","volume":"90","author":"Aschard","year":"2012","journal-title":"Am J Hum Genet"},{"key":"R6","unstructured":"ATSDR. 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